Manufacturer Supply High Purity Pharmaceutical Posaconazole Powder

China Manufacturer Supply High Purity Pharmaceutical Posaconazole Powder, Find details about China Posaconazole Powder, Posaconazole from Manufacturer Supply High Purity Pharmaceutical Posaconazole Powder

Model NO.
posaconazole
Product Name
Posaconazole Powder
Other Name
Posaconazole
Content
99%
MOQ
1kg
Appearance
White Powder
Stock
Sufficient
Shelf Life
2 Years
Sample
Avaliable
Certificate
ISO/GMP
CAS
171228-49-2
Mf
C37h42f2n8o4
Trademark
posaconazole
Transport Package
Drum
Specification
25kg/Drum
Origin
China
Model NO.
posaconazole
Product Name
Posaconazole Powder
Other Name
Posaconazole
Content
99%
MOQ
1kg
Appearance
White Powder
Stock
Sufficient
Shelf Life
2 Years
Sample
Avaliable
Certificate
ISO/GMP
CAS
171228-49-2
Mf
C37h42f2n8o4
Trademark
posaconazole
Transport Package
Drum
Specification
25kg/Drum
Origin
China

Manufacturer Supply High Purity Pharmaceutical Posaconazole Powder

 
 

Manufacturer Supply High Purity Pharmaceutical Posaconazole Powder 

Product Name:
   Posaconazole
CAS:
   171228-49-2
  MF:   C37H42F2N8O4
  Melting point :   170-172 °C
  Boiling point:   850.7±75.0 °C(Predicted)
  Density:   1.36±0.1 g/cm3(Predicted)
Brand:
 Guanlang
Purity:
 99%

Posaconazole is a broad-spectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes. Compared to other antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase. Posaconazole is the most advanced candidate for the treatment of Chagas disease. Posaconazole has entered in a phase II clinical trial in the treatment of mycoses.

Manufacturer Supply High Purity Pharmaceutical Posaconazole Powder

 Posaconazole exerts its antifungal activity by inhibiting ergosterol biosynthesis.Ergosterol is an important component necessary for fungi to maintain the structural integrity of cell membranes and to exert some membrane-related protein functions, and is also a necessary trace substance in fungal cell cycle.Posaconazole blocked ergosterol synthesis by inhibiting fungal pigment P45014a-demethylase, resulting in accumulation of 14a-methylsterol, etc. The degree of blockage was related to the sensitivity of the test strain and dosage of posaconazole.
Manufacturer Supply High Purity Pharmaceutical Posaconazole Powder

Posaconazole is used for the prophylaxis of invasive Aspergillus and Candida infections in patients who are at high risk of developing these infections due to being severely immunocompromised, such as HSCT recipients with GVHD or those with hematologic malignancies with prolonged neutropenia from chemotherapy. 
Posaconazole is also used for the treatment of oropharyngeal candidiasis (OPC), including OPC refractory to itraconazole and/or fluconazole therapy. 
Posaconazole is also used to treat invasive infections by Candida, Mucor, and Aspergillus species in severely immunocompromised patients.

Manufacturer Supply High Purity Pharmaceutical Posaconazole Powder

ItemsStandardsResults
CharacteristicsWhite to off-white powderWhite powder
IdentificationBy IRComplies
By HPLCComplies
Specific Rotation-28°~-34°-32°
Water Content≤ 2.00%0.20%
Heavy Metals≤ 10ppmComplies
Sulfated Ash≤ 0.10%0.03%
Residual SolventsN,N-dimethyl formamide: ≤880ppm27ppm
Dimethyl Sulfoxide: ≤5000ppm324ppm
Related SubstancesAny single impurity: ≤0.10%0.03%
Total Impurities: ≤0.50%0.09%
Assay
(HPLC basis on drying)
98.0%~102.0%99.98%
Reference StandardIn-house Standard
ConclusionThe product complied to In-house standard.
StoragePreserve in tight,light-resistant containers in a cool place
 
Manufacturer Supply High Purity Pharmaceutical Posaconazole PowderManufacturer Supply High Purity Pharmaceutical Posaconazole Powder