China Manufacturer Supply High Purity Pharmaceutical Posaconazole Powder, Find details about China Posaconazole Powder, Posaconazole from Manufacturer Supply High Purity Pharmaceutical Posaconazole Powder
Product Name: | Posaconazole |
CAS: | 171228-49-2 |
MF: | C37H42F2N8O4 |
Melting point : | 170-172 °C |
Boiling point: | 850.7±75.0 °C(Predicted) |
Density: | 1.36±0.1 g/cm3(Predicted) |
Brand: | Guanlang |
Purity: | 99% |
Posaconazole is a broad-spectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes. Compared to other antifungals, posaconazole is a significantly more potent inhibitor of sterol 14-alpha demethylase. Posaconazole is the most advanced candidate for the treatment of Chagas disease. Posaconazole has entered in a phase II clinical trial in the treatment of mycoses.
Posaconazole is used for the prophylaxis of invasive Aspergillus and Candida infections in patients who are at high risk of developing these infections due to being severely immunocompromised, such as HSCT recipients with GVHD or those with hematologic malignancies with prolonged neutropenia from chemotherapy.
Posaconazole is also used for the treatment of oropharyngeal candidiasis (OPC), including OPC refractory to itraconazole and/or fluconazole therapy.
Posaconazole is also used to treat invasive infections by Candida, Mucor, and Aspergillus species in severely immunocompromised patients.
Items | Standards | Results | |
Characteristics | White to off-white powder | White powder | |
Identification | By IR | Complies | |
By HPLC | Complies | ||
Specific Rotation | -28°~-34° | -32° | |
Water Content | ≤ 2.00% | 0.20% | |
Heavy Metals | ≤ 10ppm | Complies | |
Sulfated Ash | ≤ 0.10% | 0.03% | |
Residual Solvents | N,N-dimethyl formamide: ≤880ppm | 27ppm | |
Dimethyl Sulfoxide: ≤5000ppm | 324ppm | ||
Related Substances | Any single impurity: ≤0.10% | 0.03% | |
Total Impurities: ≤0.50% | 0.09% | ||
Assay (HPLC basis on drying) | 98.0%~102.0% | 99.98% | |
Reference Standard | In-house Standard | ||
Conclusion | The product complied to In-house standard. | ||
Storage | Preserve in tight,light-resistant containers in a cool place |