Oleoylethanolamine (OEA) is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-α) agonist. OEA is a naturally occurring ethanolamide lipid that regulates feeding and body weight in vertebrates ranging from mice to pythons.OEA is the monounsaturated analogue of the  anandamide, but unlike anandamide it acts independently of the pathway, regulating PPAR-α activity to stimulate lipolysis.OEA is produced by the small intestine following feeding in two steps.

Oleoylethanolamide(OEA) is a molecule produced in the body, usually found in the intestines. It is responsible for the feeling of satiety following meals. Some evidence suggests that OEA may be able to aid fat loss by acting on PPAR. When this receptor is activated in fat tissue, energy expenditure increases. So we can loss weight byoral supplementation of OEA.