China CAS 51352-87-5 Nootropic Powder Smart Drug Prl-8-53 Improving Brain Cycle, Find details about China 51352-87-5, Prl-8-53 from CAS 51352-87-5 Nootropic Powder Smart Drug Prl-8-53 Improving Brain Cycle
CAS 51352-87-5 Nootropic Powder Smart Drug PRL-8-53 Improving Brain Cycle
CAS 51352-87-5 Nootropic Powder Smart Drug PRL-8-53 Improving Brain Cycle
CAS 51352-87-5 Nootropic Powder Smart Drug PRL-8-53 Improving Brain Cycle
1) Product Name: Best Nootropics Prl-8-53(CAS 51352-87-5)
2) Specification: 99%
3) Testing Method: HPLC
4) Appearance: White powder
Item | Inspection Standard | Results |
Appearance | Off white solid powder | Conform |
Identification | Conform with NMR | Conforms |
Melting Point | 149-152°C | 150-151°C |
Loss on Drying | ≤0.50% | 0.21% |
Residue on ignition | ≤1.0% | 0.32% |
Purity(HPLC) | ≥99% | 99.2% |
Heavy metals | NMT 20PPM | Conforms |
Conclusion:This product by inspection accords with the in-house standard |
1. Enhance cognition and memory formation
2. Anxiolytic properties
3. Anti-depressive effect
4. Treatment of Alzheimer's and Parkinson's disease
5. Increase coordination
6. Improves mood
7. Help fight fatigue
8. Prevent oxidation within the brain
9. Treat alcohol related brain damage
10. Prevent caffene withdrawal symptoms
PRL-8-53 is a nootropic research chemical derived from benzoic acid and phenylmethylamine(Benzylamine) that has been shown to act as a hypermnesic drug in humans; it was first synthesized by medical chemistry professor Nikolaus Hansl at Creighton University in the 1970s as part of his work on amino ethyl meta benzoic acid esters.
The single study involving humans showed PRL-8-53 improved word recollection scores both 24 and 96 hours after initial memorization. Given the low amount of evidence available for this nootropic, we thought it relevant to reference a journal article in which the creator discusses the compound and numerous other human trials it was used in.
Anecdotal reports for this seem favorable, though in the absence of reliable published research and data for prolonged use in humans, it's not something we can recommend.
Abstract
PRL-8-53 (chemical name Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate) is a synthetic nootropic compound discovered in 1972 and patented in 1975 by the late Dr. Nikolaus Hansl, a neuropharmacologist at Creighton University in Omaha, Nebraska. Preliminary animal tests indicated that the compound was both safe and significantly nootropic, boosting avoidance learning in rodents with no adverse effects. But the real interest in PRL-8-53 was sparked by a 1978 study on human volunteers, which showed that a single dose of the compound could improve word retention scores by more than 200%
Application
PRL-8-53's exact mechanisms of action are not well understood, but it is generally believed to regulate the brain's production of and response to several crucial neurotransmitters. In his reports on human and animal studies Hansl indicated that PRL-8-53 potentiates dopamine, partially restricts production of serotonin, and enhances the brain's response to acetylcholine.
Though Hansl's research report on the 1978 human study suggests those actions, it does not clearly delineate the mechanism of action.The fact that older subjects saw the most nootropic benefit from taking the drug supports the concept that dopamine modulation plays a major role in PLR-8-53's effects. Up-regulating the normal age-related lessening of dopamine production that is associated with cognitive decline could have a significant positive impact on both learning and memory.
Dosage
The only human study on PRL-8-53 was based on the ingestion of a single 5 mg dose. There is no data on the effectiveness or potential toxicity of any other dosage in humans.
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