1. Nicergoline is an ergot derivative used to treat senile dementia and other disorders with vascular origins.
2. It has been found to increase mental agility and enhance clarity and perception.
3. It decreases vascular resistanceand increases arterial blood flow in the brain, improving the utilization of oxygen and glucose by brain cells.
4. It has similar vasoactive properties in other areas of the body, particularly the lungs.
5. It is used for vascular disorders such as cerebral thrombosis and atherosclerosis, arterial blockages in the limbs, Raynaud's disease, vascular migraines, and retinopathy.
6. Nicergoline has been registered in over fifty countries and has been used for more than three decades for the treatment of cognitive, affective, and behavioral disorders of older people.

Medrogestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone
receptor, the biological target of progestogens like progesterone. It has weak antiandrogenic, glucocorticoid,
and antimineralocorticoid activity and no other important hormonal activity.Due to its progestogenic
activity, medrogestone has antigonadotropic effects.