Factory Supply High Quality Rapamycin Powder CAS 53123-88-9
China Factory Supply High Quality Rapamycin Powder CAS 53123-88-9, Find details about China Rapamycin, Rapamycin Powder from Factory Supply High Quality Rapamycin Powder CAS 53123-88-9
Basic Info.
Model NO.
rapamycin
Mf
C36h60o30
MW
972.844
Appearance
White Solid
Storage
Desiccate at Rt
Delivery Time
7-10 Days
Valid Date
24 Months
Grade
Pharmaceutical Grade
MOQ
10g
Trademark
BIOLANG
Transport Package
Bag
Specification
10g/Bag, 1Kg/Bag
Origin
China
HS Code
2934994400
Model NO.
rapamycin
Mf
C36h60o30
MW
972.844
Appearance
White Solid
Storage
Desiccate at Rt
Delivery Time
7-10 Days
Valid Date
24 Months
Grade
Pharmaceutical Grade
MOQ
10g
Trademark
BIOLANG
Transport Package
Bag
Specification
10g/Bag, 1Kg/Bag
Origin
China
HS Code
2934994400
Product Desciption
Factory Supply High Quality Rapamycin Powder CAS 53123-88-9
Basic Infomation
Description
Rapamycin (RAPA) is a new type of macrolide immunosuppressant. It is a white solid crystal with a melting point of 183-185°C. It is lipophilic. It is soluble in organic solvents such as methanol, ethanol, acetone, and chloroform. Soluble in water, almost insoluble in ether. It was developed as early as the 1970s. It was initially used as a low-toxicity antifungal drug. In 1977, it was discovered to have immunosuppressive effects. In 1989, RAPA was used as a new drug for the treatment of organ transplant rejection. In terms of clinical application, it is a new type of immunosuppressant with good curative effect, low toxicity and no nephrotoxicity. Now it is often used as a drug to maintain the immune ability of transplanted organs (especially kidney transplantation) to slow down the immune rejection after organ transplantation. However, scientists have recently discovered another use: it can be used to treat Alzheimer's disease (senile dementia). ). What made them quite interested is that the main component of rapamycin is also a bacterial product in the isolation soil of Easter Island. The latest experiments show that the substance can be used to restore the ability of memorization defects when applied to the body of experimental mice. Rapamycin is a macrolide anti-biotin. It has a similar structure to Puracle (FK506), but it has a very different immunosuppressive mechanism. FK506 inhibits the proliferation of T lymphocytes from G0 to G1 phase, while RAPA blocks signal transduction through different cytokine receptors and blocks the process of T lymphocytes and other cells from G1 to S phase, compared with FK506 , RAPA can block the calcium-dependent and non-calcium-dependent signal transduction pathways of T lymphocytes and B lymphocytes. Medical researchers from the University of Chicago use commercially available rapamycin tablets and grapefruit juice to treat melanoma (a common malignant tumor disease in Europe and the United States), which can greatly improve the anti-cancer effects of other chemotherapy drugs, thereby prolonging the survival of patients time. Studies have shown that rapamycin is easily decomposed by enzymes after entering the digestive tract, and grapefruit juice contains a large amount of furanocoumarins, which can inhibit the damaging effect of digestive tract enzymes on rapamycin. It can improve the bioavailability of rapamycin. It is said that the earliest Dutch doctors have discovered that grapefruit juice has the effect of improving the oral absorption effect of Sandimin, and now doctors in European and American countries apply it to rapamycin preparations.
Function
Research in recent years has found that target of rapamycin (mTOR) is an intracellular kinase, and the abnormality of its conduction pathway can induce a variety of diseases. As a targeted inhibitor of mTOR, rapamycin can treat tumors closely related to this pathway, including kidney cancer, lymphoma, lung cancer, liver cancer, breast cancer, neuroendocrine cancer and gastric cancer. Especially for the treatment of two rare diseases, LAM (lymphangiomyomatosis) and TSC (tuberous sclerosis), the effect is more obvious. To some extent, LAM and TSC can also be regarded as neoplastic diseases.
About Us
SHANG HAI BIOLANG BIO-TECHNOLOGY CO.,LTD is located in shnaghai of China.We specialized in active pharmaceutical ingredient,pharmaceutical intermediates,veterinary drugs and agrochemicals.
We have strong professional research and development team, talented personnel and completely equipped laboratory for the quality controlling.Our products are exported to more than 60 countries overseas, 80% of which are exported to Europe and America, and 20% to Southeast Asia, the Middle East, South Africa and other regions. Because of excellent quality and after-sales service, our company has gained a good reputation at home and abroad.
"Quality Best,Customer First" is what we adhering,sincerely looking forward to establish long-term and mutual beneficial business relationship with worldwide customers.
Our Advantage
1.We have stock so we can delivery quickly at the very day when receive the payment.
2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order.
3.High quality guarenteed, once any problem is found, the package would be reshipped for you
4.Shipping by express (FedEx,UPS,DHL,EMS TNT HKEMS), by air . The most professional forwarder would be recommanded for you.
5 . Warm aftersale service for you 24/7 . Any of your question would be solved for the first as soon as possible . Adhering to the principle of customer first conviction . we will provide the best and the most sincere services as possible as we can.
Delivery
1. Sent out in 24hours once payment comfirm.
2. Professional agent make sure our ship fastly and safety
3.Offer your tracking number to you once we get it ,in order to facilitate you track the express
FAQ
1.Will you supply samples for test the quality?
We'd like to offer the samples for the quality evaluation,the shipping cost is borne by customers.
2.What is the payment term?
T/T, Western Union or L/C and Money Gram and BTC .
3.What is your package?
Powder: PE bag, glass bottle or PTFE bottle for inner packing
Liquid: glass bottle or PTFE bottle for inner packing
Bulk order: Fiber drum or steel drum.
4.What is your delivery term and delivery period?
FOB, CIF, etc. You can choose the one which is the most convenient or cost effective for you.The sample within 5 days, and bulk order within 7 days.
5.How to delivery by express?
A: Parcel will be shipped out in 3 working days after payment. Usually we use EMS, ePacket, Fedex, DHL, TNT and USA Domestic mixed shipping and so on.
6.Is there a discount?
A: Yes, for larger quantity, we always support with better price.
7.What's your MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
8.How to make orders?
A: Send inquiry to us,we do the offer. Payment via Western Union, Moneygram, Bank Account ect.. Then we will arrange shipping. After delivery we will offer tracking No.
Basic Infomation
Rapamycin (RAPA) is a new type of macrolide immunosuppressant. It is a white solid crystal with a melting point of 183-185°C. It is lipophilic. It is soluble in organic solvents such as methanol, ethanol, acetone, and chloroform. Soluble in water, almost insoluble in ether. It was developed as early as the 1970s. It was initially used as a low-toxicity antifungal drug. In 1977, it was discovered to have immunosuppressive effects. In 1989, RAPA was used as a new drug for the treatment of organ transplant rejection. In terms of clinical application, it is a new type of immunosuppressant with good curative effect, low toxicity and no nephrotoxicity. Now it is often used as a drug to maintain the immune ability of transplanted organs (especially kidney transplantation) to slow down the immune rejection after organ transplantation. However, scientists have recently discovered another use: it can be used to treat Alzheimer's disease (senile dementia). ). What made them quite interested is that the main component of rapamycin is also a bacterial product in the isolation soil of Easter Island. The latest experiments show that the substance can be used to restore the ability of memorization defects when applied to the body of experimental mice. Rapamycin is a macrolide anti-biotin. It has a similar structure to Puracle (FK506), but it has a very different immunosuppressive mechanism. FK506 inhibits the proliferation of T lymphocytes from G0 to G1 phase, while RAPA blocks signal transduction through different cytokine receptors and blocks the process of T lymphocytes and other cells from G1 to S phase, compared with FK506 , RAPA can block the calcium-dependent and non-calcium-dependent signal transduction pathways of T lymphocytes and B lymphocytes. Medical researchers from the University of Chicago use commercially available rapamycin tablets and grapefruit juice to treat melanoma (a common malignant tumor disease in Europe and the United States), which can greatly improve the anti-cancer effects of other chemotherapy drugs, thereby prolonging the survival of patients time. Studies have shown that rapamycin is easily decomposed by enzymes after entering the digestive tract, and grapefruit juice contains a large amount of furanocoumarins, which can inhibit the damaging effect of digestive tract enzymes on rapamycin. It can improve the bioavailability of rapamycin. It is said that the earliest Dutch doctors have discovered that grapefruit juice has the effect of improving the oral absorption effect of Sandimin, and now doctors in European and American countries apply it to rapamycin preparations.
Function
Research in recent years has found that target of rapamycin (mTOR) is an intracellular kinase, and the abnormality of its conduction pathway can induce a variety of diseases. As a targeted inhibitor of mTOR, rapamycin can treat tumors closely related to this pathway, including kidney cancer, lymphoma, lung cancer, liver cancer, breast cancer, neuroendocrine cancer and gastric cancer. Especially for the treatment of two rare diseases, LAM (lymphangiomyomatosis) and TSC (tuberous sclerosis), the effect is more obvious. To some extent, LAM and TSC can also be regarded as neoplastic diseases.
About UsSHANG HAI BIOLANG BIO-TECHNOLOGY CO.,LTD is located in shnaghai of China.We specialized in active pharmaceutical ingredient,pharmaceutical intermediates,veterinary drugs and agrochemicals.
We have strong professional research and development team, talented personnel and completely equipped laboratory for the quality controlling.Our products are exported to more than 60 countries overseas, 80% of which are exported to Europe and America, and 20% to Southeast Asia, the Middle East, South Africa and other regions. Because of excellent quality and after-sales service, our company has gained a good reputation at home and abroad.
"Quality Best,Customer First" is what we adhering,sincerely looking forward to establish long-term and mutual beneficial business relationship with worldwide customers.
Our Advantage1.We have stock so we can delivery quickly at the very day when receive the payment.
2.Best price, first class service, high successful delivery rate. A discount would be given when you make a large order.
3.High quality guarenteed, once any problem is found, the package would be reshipped for you
4.Shipping by express (FedEx,UPS,DHL,EMS TNT HKEMS), by air . The most professional forwarder would be recommanded for you.
5 . Warm aftersale service for you 24/7 . Any of your question would be solved for the first as soon as possible . Adhering to the principle of customer first conviction . we will provide the best and the most sincere services as possible as we can.
Delivery
1. Sent out in 24hours once payment comfirm.
2. Professional agent make sure our ship fastly and safety
3.Offer your tracking number to you once we get it ,in order to facilitate you track the express
FAQ
1.Will you supply samples for test the quality?
We'd like to offer the samples for the quality evaluation,the shipping cost is borne by customers.
2.What is the payment term?
T/T, Western Union or L/C and Money Gram and BTC .
3.What is your package?
Powder: PE bag, glass bottle or PTFE bottle for inner packing
Liquid: glass bottle or PTFE bottle for inner packing
Bulk order: Fiber drum or steel drum.
4.What is your delivery term and delivery period?
FOB, CIF, etc. You can choose the one which is the most convenient or cost effective for you.The sample within 5 days, and bulk order within 7 days.
5.How to delivery by express?
A: Parcel will be shipped out in 3 working days after payment. Usually we use EMS, ePacket, Fedex, DHL, TNT and USA Domestic mixed shipping and so on.
6.Is there a discount?
A: Yes, for larger quantity, we always support with better price.
7.What's your MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
8.How to make orders?
A: Send inquiry to us,we do the offer. Payment via Western Union, Moneygram, Bank Account ect.. Then we will arrange shipping. After delivery we will offer tracking No.
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