99%CAS 155141-29-0 Rosiglitazone Maleate powder Rosiglitazone Maleate Material Rosiglitazone Maleate
Product Description
Product Name | Rosiglitazone Maleate |
CAS | 155141-29-0 |
Appearance | White crystalline powder |
MF | C22H23N3O7S |
MW | 473.49892 |
Purity | 99% |
Shelf Life | 2 Years |
Rosiglitazone is currently the clinical treatment of diabetes commonly used thiazolidinedione hypoglycemic agents, this product is insulin sensitizer, by increasing the skeletal muscle, liver, adipose tissue sensitivity to insulin, improve cell pairs Glucose utilization and play a lower blood sugar effect, can significantly reduce the fasting blood glucose and insulin, C peptide levels, postprandial blood glucose and insulin also have a lower effect.
But requires patients to have a certain ability to secrete insulin. Clinical application for diet control and exercise is still not satisfied with type 2 diabetes patients, but also with biguanide or sulfonylurea combination therapy alone when the poor control of blood sugar. Single use, the initial dose of oral daily 4mg, 12 weeks after the need to increase to 8mg daily. In fasting or eating clothes After the elderly patients may have mild to moderate edema and anemia, edema patients with caution. Sample Display
Function & Application
Rosiglitazone maleate is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).
Rosiglitazone maleate is a potent and selective activator of PPARγ, with EC50s of 30 nM, 100 nM and 60 nM for PPARγ1, PPARγ2, and PPARγ, respectively, and a Kd of appr 40 nM for PPARγ; Rosiglitazone maleate is also an modulator of TRP channels, inhibits TRP melastatin 2 (TRPM2), TRPM3 and activates TRP canonical 5 (TRPC5).Specification
Packaging & Shipping
Certifications
Our Team
About Us