Anti -P21 Rabbit Primary Antibody

China Anti -P21 Rabbit Primary Antibody, Find details about China for Research Only, Liquid from Anti -P21 Rabbit Primary Antibody

Basic Info.

HS Code

3502900000

HS Code

3502900000

Product Desciption

Anti -p27 KIP 1 Rabbit Primary Antibody
Product information

Anti -P21 Rabbit Primary Antibody

Product information

Description	P21 rabbit polyclonal
Protein full name	Cyclin-dependent kinase inhibitor 1
Synonyms	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21,SDI1,WAF1,p21CIP1, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse P21
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm, Nucleus
Uniprot ID	P38936, P39689

Applications

Applications	IHC, IF
Species	Human, Mouse, Rat
Dilution	1:200-1:800
Positive tissue	Hela, kidney, brain, heart, inflammatory lung

Background

May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding.

Images

	Immunohistochemistry analysis of paraffin-embedded mice hela tumor using P21 (GB11153) at dilution of 1:800.
	Immunohistochemistry analysis of paraffin-embedded rat kidney in using P21 (GB11153) at dilution of 1:400
	Immunohistochemistry analysis of paraffin-embedded tumour by rat brain using P21 (GB11153) at dilution of 1:400
	Immunohistochemistry analysis of paraffin-embedded mouse kidney in using P21(GB11153) at dilution of 1:200
	Immunohistochemistry analysis of paraffin-embedded mouse inflammatory lung in using P21(GB11153) at dilution of 1:400
	Immunohistochemistry analysis of paraffin-embedded mouse heart in using P21(GB11153) at dilution of 1:400

Storage

Storage	Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

Applications

Applications	IHC	IF
Species	Human, Mouse, Rat	Human, Mouse, Rat
Dilution	1:400	1:100-1:400
Positive tissue	liver cancer, lung cancer, testis, spleen	brain

Background

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.

Storage

Storage	Store at -20 ºC for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

Anti -P21 Rabbit Primary Antibody