99% Purity Nootropic Nutrition Supplements CAS 156223-05-1 Bulk Dmxb-a / Gts-21 Powder
China 99% Purity Nootropic Nutrition Supplements CAS 156223-05-1 Bulk Dmxb-a / Gts-21 Powder, Find details about China CAS 156223-05-1, Dmxb-a from 99% Purity Nootropic Nutrition Supplements CAS 156223-05-1 Bulk Dmxb-a / Gts-21 Powder
Basic Info.
CAS No.
156223-05-1
Other Names
Nefiracetam
Mf
C19h22cl2n2o2
Grade
Pharmaceutical Grade
Shelf Life
2 Years
Type
Antibiotic and Antimicrobial Agents
Trademark
Greenway Biotech
Transport Package
Paper Bag or Drum
Specification
1kg/bag; 25kg/drum
Origin
China
HS Code
2942000000
CAS No.
156223-05-1
Other Names
Nefiracetam
Mf
C19h22cl2n2o2
Grade
Pharmaceutical Grade
Shelf Life
2 Years
Type
Antibiotic and Antimicrobial Agents
Trademark
Greenway Biotech
Transport Package
Paper Bag or Drum
Specification
1kg/bag; 25kg/drum
Origin
China
HS Code
2942000000
Product Desciption
99% Purity Nootropic Nutrition Supplements CAS 156223-05-1 Bulk DMXB-A /
GTS-21 Powder
Description:
GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective
alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and
cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive
rights to the compound and a related library of analogs as part of the acquisition of Osprey
Pharmaceutical Company in April 2006. GTS-21 has been studied in multiple Phase I studies
in healthy volunteers and one Phase I/II study in schizophrenic patients. In all studies, the
compound was well tolerated. In a Phase I multi-dose, double-blind, placebo controlled study
in healthy adults, GTS-21 also demonstrated cognitive enhancement across all doses, with a
statistically significant improvement in attention related and memory related tasks.
GTS-21 was O-demethylated to yield compounds that were then subject to glucuronidation.
Three of the metabolites in rat urine were isolated and characterized as 4-OH-GTS-21,
4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. The major urinary metabolites
were 4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. In vitro chemical inhibition
of cytochrome P450 in human liver microsomes indicated that CYPIA2 and CYP2E1 were the
isoforms primarily responsible for the O-demethylation of GTS-21, with some contribution from
CYP3A.
Application&Function:
DMBX-anabaseine (DMBX-A) is a derivative of the natural product anabaseine that acts as a
partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7
subtypes, but activates only the α7 to any significant extent.
GTS-21 Powder
| Product Name | DMXB-A / GTS-21 Powder |
| Brand Name | Greenway Biotech |
| Purity | 99% |
| CAS No. | 156223-05-1 |
| Appearance | White Powder |
| Test Method | HPLC |
Description:
GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective
alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and
cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive
rights to the compound and a related library of analogs as part of the acquisition of Osprey
Pharmaceutical Company in April 2006. GTS-21 has been studied in multiple Phase I studies
in healthy volunteers and one Phase I/II study in schizophrenic patients. In all studies, the
compound was well tolerated. In a Phase I multi-dose, double-blind, placebo controlled study
in healthy adults, GTS-21 also demonstrated cognitive enhancement across all doses, with a
statistically significant improvement in attention related and memory related tasks.
GTS-21 was O-demethylated to yield compounds that were then subject to glucuronidation.
Three of the metabolites in rat urine were isolated and characterized as 4-OH-GTS-21,
4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. The major urinary metabolites
were 4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. In vitro chemical inhibition
of cytochrome P450 in human liver microsomes indicated that CYPIA2 and CYP2E1 were the
isoforms primarily responsible for the O-demethylation of GTS-21, with some contribution from
CYP3A.
Application&Function:
DMBX-anabaseine (DMBX-A) is a derivative of the natural product anabaseine that acts as a
partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7
subtypes, but activates only the α7 to any significant extent.
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