Ginsenoside Ra1

Alias : (3beta,12beta)-12-hydroxy-20-((o-beta-d-xylopyranosyl-(1→4)-o-alpha-l-arabinopyranosyl-(1→6)-beta-d-glucopyranosyl)oxy)dammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside

 

Ginsenoside Ra1 Chemical Structure

 

Price & Stock

Ginsenoside Ra1 is extracted from roots and rhizomes of Panax ginseng, shows inhibitory effects on protein tyrosine kinase.

 

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Biological Activity

IC50 Value & Target: 
In Vitro: Ra1 and Ro showed significant inhibitory effects on PTK activation induced by H/R. Dose-response experiments revealed that ginsenoside-Rb1 was the most active compound and it completely blocked PTK activation at a wide range of concentrations. Most protopanaxadiol-type ginsenosides and some protopanaxatriol type saponins also showed significant effects on PTK activation.[1]. 
In Vivo: Have no relevant experimental datas.

Chemical Information

Ginsenoside Ro

Alias : Chikusetsusaponin 5; Chikusetsusaponin V; Polysciasaponin P3; (3beta)-28-(beta-d-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranosiduronic acid

 

Ginsenoside Ro Chemical Structure

 Datasheet Download

• Ginsenoside-Ro .pdf

Price & Stock

Ginsenoside Ro, the predominant ginsenoside in the rhizome, is reported to have anti-inflammtory, anti-hepatitic activities, and showed inhibitory activity against 5αR with IC(50) value of 259.4 μm.

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Biological Activity

IC50 Value & Target: 259.4 μm (for 5α-reductase ) 
In Vitro: Ginsenoside Ro exhibited suppressive activities on reactive oxygen species and matrix metalloproteinase-2 elevation in UV-B-irradiated fibroblasts. Ginsenoside Ro could overcome the reduction of the total glutathione contents in UV-B-irradiated fibroblasts. In IL-1β-induced rat chondrocytes, ginsenoside Ro exerted anti-apoptosis and anti-inflammation. Ro could improve IL-1β-induced chondrocytes viability. Ginsenoside Ro could suppress IL-1β-induced apoptosis by inhibiting levels of Bax and Bad, decreasing p53 phosphorylation and promoting the expression of Bcl-xL and PCNA. Ginsenoside Ro inhibited caspase 3 activity. IL-1β-induced inflammation and matrix degration were also alleviated by Ginsenoside Ro with down-regulating the expression of MMP 3, MMP 9 and COX-2. Moreover, ginsenoside Ro inhibited NF-κB p65 phosphorylation induced by IL-1β [2]. 
In Vivo: Topical administration of ginsenoside Ro (0.2 mg/mouse) to shaved skin inhibited hair re-growth suppression after shaving in the testosterone-treated C57BL/6 mice. Ginsenoside Ro showed inhibitory activity against 5αR with IC(50) value of 259.4 μm [3].

Chemical Information

English Name: Ginseng P.E
Latin Name: Panax ginseng C.A. Mey.
Source of Plant: China is the origin of ginseng and has 2, 000 years of medical history in China; as the rare materia medica known all around the world, it has been included in many countries Pharmacopoeia. Ginseng Panax locates in the northeast region of China, North Korea and the Far East region of the former Soviet Union.
Used Part: Extracted and refined from the Dried Root of panax ginseng
 
Active Ingredient: Total Ginsenosides
 
1)Ginsenoside Rg1
Molecular Formula :C42H72O14
Molecular Weight :801.02
CAS Number:22427-39-0  
 
2)Ginsenoside Rb1
Molecular Formula :C54H92O23
Molecular Weight :1109.31
CAS Number:41753-43-9
 
3)Ginsenoside Re
Molecular Formula :C48H82O18
Molecular Weight :947.16
CAS Number:52286-59-6
 
Specification: Total Ginsenosides content 10%-80%
Characteristic:
Appearance:Yellow-White powder
Odor: Special Ginsenoside aroma, bitter taste
Solubility: 100% Soluble in Water
 
Function:
Enhance the immune system; can resist caducity and fatigue, nourishing brain; Regulate nerve system and improve human hematopoietic function, promote the function of metabolism; reduce blood sugar, treat coronary heart disease, angina pectoris, bradycardia, arrhythmia, ventricular, extrasystole. Irregular blood pressure, weak nerves resulting from child-birth; Enhance memory, skin cell activation, enhance the skin elasticity, reduce furrow.  
 
Application:
Medicine and health industry, cosmetology and cosmetics industry, and food additives. In many countries, ginseng is one of the most popular plants tonics.
 
Shelf Life: Two years when properly stored.
Storage: Store in Cool and dry place, keep sealed and keep away from strong light, hight temperature.
Packing: Double plastic bag of foodstuff inside, cardboard drum outside, (25kg/drum)
 


 
(EYECHEM) Xi'an QingShuo import and export trade Co., Ltd. Is a source and supplier of plants ingredients by making use of local rich herbs resources and mature technology of plant extraction. We devote ourself to specialty food and nutraceutical industries. Such as herbs extracts, nutraceutical industries, pharmaceutical ingredients, food additives, cosmetics ingredients, agriculture husbandry ingredients, flavoring, etc. 

We have factory of 10 years history of production, Named "Xi'an QingYue biological technology Co., Ltd. (QINGHERB)". We have passed certification of KOSHER, HALAL, ISO9001 ISO22000, HACCP. In to try for GAP/GMP. Now, quality department has a lot of advanced testing equipment, such as high performance liquid chromatography (HPLC), gas chromatography (GC), evaporative light-scattering light detector (ELSD), etc. 

Its main products are Cytisine, Aesculetin/Aesculin, Puerarin/Pueraria flavone, Epimedium P. E(Icariin/Flavone), Tabersonine, Fungus/Mushroom extract, Ginseng extract, Fruit extract, Sophora japonica P. E. Rutin, Quercetin, Genistein. Camptothecine. 

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