Popular Products Gw0742 CAS 317318-84-6 Door to Door Purity Best Price Powder Canada Large Stock

China Popular Products Gw0742 CAS 317318-84-6 Door to Door Purity Best Price Powder Canada Large Stock, Find details about China 99% Purity, Chemical Materials from Popular Products Gw0742 CAS 317318-84-6 Door to Door Purity Best Price Powder Canada Large Stock

Basic Info.

Model NO.

317318-84-6

Appearance

White Powder

Molecular Formula

C21h17f4no3s2

Grade

Pharmaceutical Grade

Trademark

Wingroup

Transport Package

Drum / Aluminum Foil Bag

Origin

Wuhan, China

Model NO.

317318-84-6

Appearance

White Powder

Molecular Formula

C21h17f4no3s2

Grade

Pharmaceutical Grade

Trademark

Wingroup

Transport Package

Drum / Aluminum Foil Bag

Origin

Wuhan, China

Product Desciption

Product Name	GW0742
Synonyms	2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy);GW0742X;GW610742;GWdelta0742;2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenChemicalbooko;GW0742;[4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETICACID;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETICACID
CAS NO	317318-84-6
Molecular Formula	C21H17F4NO3S2
Molecular Weight	471.49
Melting point	134.5-135.5 °C
Boiling Point	591.5±60.0 °C(Predicted)
Flash Point	311.5±32.9 °C
Density	1.46±0.1 g/cm3(Predicted)
Purity	≥98% (HPLC)
Grade	Pharmaceutical Grade
Solubility	Chloro-form (Slightly), Me-thanol (Slightly)
Appearance	White Powder
Storage	store at dry and cool place
Packing and Shipping	Packing: Drum / Aluminum Foil Bag / According to customer's requiement Shipping: 3-5 working days after receive payment, by Fedex,UPS,EMS,DHL,Sea and air transport
Usage	It is the best in terms of endurance, energy, endurance and any type of performance improvement

Description:

Popular Products Gw0742 CAS 317318-84-6 Door to Door Purity Best Price Powder Canada Large Stock

GW0742 (also known as GW610742) is a PPARδ/β agonist that is investigated for drug use.GW0742 is mixed PPAR-B agonist antagonist depending on its dosage.GW0742 has weak activity on multiple nuclear receptors as well. It is antagonistic at androgen receptors and VDR.In silico modelling suggest that it has effects on thyroid hormone receptors.Multiple derivaties of GW0742 core structure has been developed. One of the compound,

which has thiazole ring replaced with an oxazole ring inhibited VDR-meditated transcription with IC50 of 660 nM.Other novel analgos which are more potent than GWO742 with reduced toxicity has been developed as well.

Reference:

1. "Cayman Chemical GW0742". Retrieved 31 Mar 2013.

2. Smith SA, Monteith GR, Robinson JA, Venkata NG, May FJ, Roberts-Thomson SJ (July 2004). "Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons". Journal of Neuroscience Research. 77 (2): 240-9. doi:10.1002/jnr.20153. PMID 15211590. S2CID 21295375.

3. Haskova Z, Hoang B, Luo G, Morgan LA, Billin AN, Barone FC, et al. (July 2008). "Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARbeta/delta ligand GW0742". Inflammation Research. 57 (7): 314-21. doi:10.1007/s00011-007-7157-4. PMID 18622687. S2CID 25631088.

4. Sznaidman ML, Haffner CD, Maloney PR, Fivush A, Chao E, Goreham D, Sierra ML, LeGrumelec C, Xu HE, Montana VG, Lambert MH, Willson TM, Oliver WR, Sternbach DD (May 2003). "Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)--synthesis and biological activity". Bioorganic & Medicinal Chemistry Letters. 13 (9): 1517-21. doi:10.1016/s0960-894x(03)00207-5. PMID 12699745.