1.Taxol is a mitotic inhibitor drup used in the treatment of cancer.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
3. Taxol has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
4.Taxol is also used for the prevention of restenosis (recurrent narrowing) of coronary stents, locally delivered to the wall of the coronary artery, a Taxol paclitaxel coating limits the growth of neointima (scar tissue) within stents.
Taxol stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes.