1). As an important signal transduction molecule in the development of the eyeball, retinaldehyde plays many important roles in the development of the vertebrate eyeball. Myopia is a developmental disease. The active expansion of the myopic eye Sclera is an important mechanism for its elongation. The acetal may be a messenger molecule that regulates the elongation of the experimental myopic eye, and the relationship between the occurrence and development of acetal and experimental myopia. Make some progress, This study reviewed the development of retinaldehyde and its nuclear receptors, the retina, choroid, scleral changes in the experimental myopia of the eyeball, and its use as a messenger molecule to transmit an elongation signal from the retina to the Sclera.