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Product Name | Phinacetin |
CAS No | 62/44*2 |
MF | C10H13NO2 |
MW | 179.2158 |
Purity | 99% |
Appearance | White Crystal Powder or Fluffy Fine Powder |
Mesh | 40 Mesh or 80 Mesh |
Phinacetin is a pain-relieving and fever-reducing drug, widely used from its introduction in 1887 until banned in the US by the FDA in 1983. Its use has declined because of its adverse effects, which include increased risk of certain cancers and kidney damage. It is metabolized into paracetamol, which replaced it in some over-the-counter medications following the ban on Phinacetin.
Phinacetin is a white crystalline powder with the chemical composition C10H13NO2. It was first developed by Harmon Northrop Morse in 1878. In addition to its pain-reducing properties, it also has been used as a fever-reducer, a treatment for rheumatoid arthritis and a treatment for intercostal neuralgia, a rare disorder that causes pain in the nerves around the ribs. It was one of the first painkillers that was not derived from opiu while at the same time being absent of anti-inflammatory qualities.
Phinacetin Is a drug that relieves pain and reduces fever, which is metabolized to acetami, it is replaced by some non-prescription drugs.
The analgesic effect is due to its effect on the spinal cord sensory tract. In addition, Phinacetin has an inhibitory effect on the heart as a negative intramuscular injection. It is antipyretic, acts on the brain to lower the temperature set point. It can also be used to treat rheumatoid arthritis (subacute) and intercostal neuralgia.
Items of analysis | Specification | Results | |
Description | Should comply with the standard | Comforms | |
Identification | Positive | Positive | |
Melting point | 134ºC to 136.5ºC | 134.5ºC to 136.5ºC | |
4-chloroacetan | BP1968 | <3.5ml/0.6g | |
P-Phinacetin | BP1968 | Comforms | |
Sulphated ash | ≤0.1% | 0.07% | |
Assay | ≥99% | 99.10% | |
Conclusion | BP68 Standard |