Description:

Levamisole is an anthelminthic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives.

Indications:

Levamisole is indicated for the treatment of many nematodes in cattle, sheep, goats and poultry. In sheep and cattle, Levamisole has relatively good activity against cecum nematodes, small intestinal nematodes (not particularly effective against Strongyloides spp.), large intestinal nematodes (not Trichuris spp.), and lungworms. Adult forms of species that are usually susceptible to Levamisole include: Haemonchus spp., Trichostrongylus spp., Ostertagia spp., Cooperia spp., Nematodirus spp., Bunostomum spp., Oesophagostomum spp., Chabertia spp., and Dictyocaulus viviparous. Levamisole is less effective against the immature forms of these parasites.

Contra Indications:

no

Side Effects:

Symptoms of Levamisole toxicity often mimic those of organophosphate toxicity. Symptoms may include hyper-salivation, hyper-esthesia and irritability, clonic seizures, CNS depression, dyspnea, defecation, urination, and collapse. These effects are best treated by supportive means, as animals generally recover within hours of dosing. Acute Levamisole over-dosage can result in death due to respiratory failure. Should respiratory failure occur, artificial ventilation with oxygen should be instituted until recovery takes place.

Dosage:

For cattle, sheep and goats: per 2kg of body weight for oral dosing;For poultry: 25mg per 2kg of body weight for oral dosing.

Withdrawal Times:

- Meat:Cattle: 2 daysSheep: 3 days- Milk: 1day