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Supply Camptotheca Acuminata Extract 10-Hydroxy Camptothecin Powder 98% CAS 19685-09-7

China Supply Camptotheca Acuminata Extract 10-Hydroxy Camptothecin Powder 98% CAS 19685-09-7, Find details about China 10-Hydroxycamptothecin, 19685-09-7 from Supply Camptotheca Acuminata Extract 10-Hydroxy Camptothecin Powder 98% CAS 19685-09-7

Transport Package
25kg/Drum
Specification
99%
Origin
China
Transport Package
25kg/Drum
Specification
99%
Origin
China
10-Hydroxycamptothecin CAS 19685-09-7

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Product  Name10-Hydroxycamptothecin
CAS No.19685-09-7
Appearanceyellow powder
Purity99.0%  
impurities≤0.1%
Packing220kg/drum; 
Delivery  Time2-15 days
StorageDry and cool place and keep sealed away from strong light
Place of OriginChina
CustomsFree of customs (door to door)
SampleAvailable
Shelf life2 years
PaymentT/T,BTC,WU,Credit Card (Safe delivery door to door)

1.Product Information

Quick Details
Type:Other
Form:Powder
Part:Fruit and leaf
Extraction Type:Solvent Extraction
Grade:AAAAA
Model Number:Botanical Extract
Product Name:Acuminata Extract
Test Method:HPLC TLC
Appearance:white powder
Assay:HPLC 10%-99%

2.Application 

Camptothecin is an alkaloid derived from the chinese tree Camptotheca acuminata Decne.

 Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I,

 by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately

 causes tumor cell death. In clinical it is widely believed that camptothecin analogs exhibited 

remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, 

it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes.

 If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein 

cannot be synthesized, it ultimately causes cell death. Application of 

camptothecin in clinic is limited due to serious side effects and poor water-solubility. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous 

therapy such as topotecan and irinotecan while others have been obtained satisfying 

curative effects in clinic.

 

1) Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, 

by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately 

causes tumor cell death.

2) In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, 

it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes.

 If the chromosomes cannot be unwound, transcription of DNA message cannot occur and

 the protein cannot be synthesized, it ultimately causes cell death.

3) Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility. 4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy

 such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.


Supply Camptotheca Acuminata Extract 10-Hydroxy Camptothecin Powder 98% CAS 19685-09-7Supply Camptotheca Acuminata Extract 10-Hydroxy Camptothecin Powder 98% CAS 19685-09-7Supply Camptotheca Acuminata Extract 10-Hydroxy Camptothecin Powder 98% CAS 19685-09-7
Supply Camptotheca Acuminata Extract 10-Hydroxy Camptothecin Powder 98% CAS 19685-09-7
Supply Camptotheca Acuminata Extract 10-Hydroxy Camptothecin Powder 98% CAS 19685-09-7
Supply Camptotheca Acuminata Extract 10-Hydroxy Camptothecin Powder 98% CAS 19685-09-7Supply Camptotheca Acuminata Extract 10-Hydroxy Camptothecin Powder 98% CAS 19685-09-7

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