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Introduction
Product Name | Pharmaceutical Powder 99% CAS 60142-96-3 Gabapentin Powder |
CAS | 60142-96-3 |
Appearance | White Powder |
Molecular formula | C9H17NO2 |
Molecular Weight | 171.24 |
Assay | 98% |
Shelf Life | 24 months when properly stored |
Storage | Keep in a cool, dry, dark location |
Gabapentin is structurally similar to GABA (sc-203053; -aminobutyric acid) and is reported in various research studies to increase GABA concentrations within the brain. Gabapentin is also noted to bind to a novel site on voltage-sensitive Ca2+ channels. Additionally, Gabapentin is reported to demonstrate inhibition of dopamine release from caudate nucleus, prevent neuronal cell death, and is antinociceptive.
Gabapentin (GPN) marketed under the brand name Neurontin among others, is a medication used to treat epilepsy,neuropathic pain, hot flashes, and restless leg syndrome.In epilepsy it may be used for those with partial seizures. It is recommended as one of a number of first line medications for the treatment of neuropathic pain indiabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain. For neuropathic pain about 14% of people have a meaningful benefit.
Function
Gabapentin is an anticonvulsant that is chemically unrelated to any other anticonvulsant or mood regulating medication. Gabapentin received final approval for marketing in the USA on 30 December 1993 and is labeled only for use as an anticonvulsant. It is also widely used to treat individuals suffering from many kinds of pain problems, tremors, restless legs syndrome, hot flashes associated with menopause, and various psychiatric disorders.
Gabapentin is structurally similar to GABA (sc-203053; -aminobutyric acid) and is reported in various research studies to increase GABA concentrations within the brain. Gabapentin is also noted to bind to a novel site on voltage-sensitive Ca2+ channels.
Additionally, Gabapentin is reported to demonstrate inhibition of dopamine release from caudate nucleus, preventneuronal cell death, and is antinociceptive.
Specification
Test items | Standard | Result | ||
appearance | white crystalline powder | white crystalline powder | ||
identification | IR spectrum should comply with the CRS | conform | ||
PH | 6.5-8.0 | 7.2 | ||
water | not more than 0.5% | 0.0% | ||
resiude on ignition | not more than 0.1% | 0.0% | ||
heavy metals | not more than 0.02% | less than 0.002% | ||
impurity A | not more than 0.1% | <0.02% | ||
impurity B | not more than 0.06% | <0.02% | ||
impurity E | not more than 0.1% | <0.02% | ||
impurity CDMA | not more than 0.1% | <0.02% | ||
max individual unknown impurity | not more than 0.1% | <0.03% | ||
impurity D | not more than 0.1% | <0.02% | ||
impurity CAI | not more than 0.1% | <0.02% | ||
max individual unknown impurity | not more than 0.1% | <0.02% | ||
total impurity | not more than 0.5% | 0.0% | ||
methanol | not more than 3000ppm | 55ppm | ||
not more than 5000ppm | 52ppm | |||
methylene chloride | not more than 600ppm | N.D | ||
not more than 890ppm | N.D | |||
assay | 98.0%~102.0% | 99.4% |