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CB-03-01 Hair Loss Treatment Raw Powder CAS 19608 -29-8 CB-03-01

China CB-03-01 Hair Loss Treatment Raw Powder CAS 19608-29-8 CB-03-01, Find details about China Hair Loss, CB-03-01 from CB-03-01 Hair Loss Treatment Raw Powder CAS 19608-29-8 CB-03-01

Model NO.
CB-03-01
Trademark
Desheng
Transport Package
Drum, Carton
Specification
NA
Origin
China
HS Code
2925290090
Model NO.
CB-03-01
Trademark
Desheng
Transport Package
Drum, Carton
Specification
NA
Origin
China
HS Code
2925290090
CB-03-01 Hair Loss Treatment Raw Powder CAS 19608-29-8 CB-03-01
B-03-01 Hair Loss Treatment Raw Powder CAS 19608-29-8 CB-03-01
CB-03-01 Hair Loss Treatment Raw Powder CAS 19608-29-8 CB-03-01

Description:

Cortexolone 17α-propionate (developmental code name CB-03-01), or 11-deoxycortisol 17α-propionate, is a synthetic steroidal antiandrogen-specifically, an androgen receptor antagonist - which is used as a topical medication in the treatment of androgen-dependent conditions including acne vulgaris and androgenic alopecia (male-pattern hair loss). It is the C17α propionate ester of 11-deoxycortisol (cortexolone); C17α esters of 11-deoxycortisol were unexpectedly found to possess antiandrogen activity, and cortexolone 17α-propionate was selected for development based on its optimum drug profile.

Function:

CB-03-01 is the drug for the treatment of hair loss dwindled. It has same function and application with RU58841 and Setipiprant.
CB-03-01 is a molecule that acts at the level of the skin, blocking dihydrotestosterone (DHT) from binding to the receptor in the cell. The molecule has a unique mechanism that acts at the skin surface, and is quickly metabolized to free inactive cortexolone, a substance naturally found in the body. The molecule has been evaluated in a variety of animal models as well as initial human trials in Europe. The results of these studies demonstrate that CB-03-01 appears to have potent activity without significant local or systemic side effects.

Application: 

Cortexolone 17α-propionate (developmental code name CB-03-01), or 11-deoxycortisol 17α-propionate, is a synthetic steroidal antiandrogen-specifically, an androgen receptor antagonist - which is used as a topical medication in the treatment of androgen-dependent conditions including acne vulgaris and androgenic alopecia (male-pattern hair loss). It is the C17α propionate ester of 11-deoxycortisol (cortexolone); C17α esters of 11-deoxycortisol were unexpectedly found to possess antiandrogen activity, and cortexolone 17α-propionate was selected for development based on its optimum drug profile.

COA:

Items

Requirements

Results

Appearance:

White Powder

 White Powder

Identification

 

 

HPLC

IR spectra is consistent with CRS

Conforms

Sulphated Ash 

≤0.1%

0.01%

Loss on drying

≤0.5%

0.38%

Related substances 

Impurity A ≤0.1%

Impurity B ≤0.2%

Any other Impurity ≤0.1%

All other Impurity A ≤0.2%

<0.1%

<0.2%

<0.1%

<0.2%

Heavy metal

Pb :

Cadmium(Cd) :

As :

Hg:

≤ 10ppm

<1 ppm

<0.5 ppm

<10ppm

< 1 ppm

<10ppm

Conforms

0.3ppm

Conforms

Negative

Assay

≥99%99.5%

Conclusion:

The product conforms to BP.

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