China GMP Factory Direct Supply 99% Purity Tetracaine HCl / Tetracaine Hydrochloride Powder CAS: 136-47-0, Find details about China Tetracaine HCl, Tetracaine HCl Powder from China GMP Factory Direct Supply 99% Purity Tetracaine HCl / Tetracaine Hydrochloride Powder CAS: 136-47-0
Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores.
Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
In the manufacture of pharmaceutical preparation for external use, to relieve the pain of drugs or medication lesions pain.
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Items | QUALITY STANDARDS | RESULTS |
Description | White or almost white crystalline powder | White crystalline powder |
Solubility | Matching with the working standard | Complies |
Identification | A.By IR, To match with working standard | Complies |
B: To 10ml of solution S add 1ml of ammonium thiocyanate solution R.A white,crystalline precipitate is formed which,after recrystallisation from water R and drying at 80ºC for 2h,melts at about 131ºC | Complies | |
C. To about 5mg add 0.5ml of fuming nitric acid R .Evaporate to dryness on a water-bath,allow to cool and dissolve the residue in 5ml of ace R.Add 1ml of 0.1M alcoholic potassium hydroxide.A violet colour develops | Complies | |
D. Solution S gives reaction of chlorides. | Complies | |
PH | 4.5~6.5 | 5.78 |
Residual Solvents | Conform to standard | Complies |
Claruty | Solution should be clear | Complies |
Related Substances | Conform to standard | Complies |
Heavy metals | ≤10ppm | <10ppm |
Loss on drying | ≤1.0% | 0.87% |
Resiue on ignition | ≤0.1% | 0.05% |
Melting range | 148ºC | 147.5ºC~150.8ºC |
Assay(*) | 99%~101.0% | 100.40% |
Conclusion | The Sample Complies With Specification of EP8 |
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