China CAS 540737-29-9 Tofacitinib Citrate with Highest Quality, Find details about China Tofacitinib Citrate, Tofacitinib Intermediate from CAS 540737-29-9 Tofacitinib Citrate with Highest Quality
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Product Name: | Tofacitinib Citrate |
CAS: | 540737-29-9 |
MF: | C16H20N6O.C6H8O7 |
MW: | 289.35 |
Tofacitinib citrate is an oral drug used for treating rheumatoid arthritis. It belongs to a class of drugs called Janus kinase (JAK) inhibitors. JAKs are enzymes (proteins) that regulate chemical signaling pathways that control biologic processes such as blood formation and the immune response that causes the pain, tenderness and swelling of inflammation. JAKs are found in many cells, especially stem cells in bones and joints. Inhibition of JAKs by tofacitinib prevents inflammation and tissue destruction that is associated with the inflammation of rheumatoid arthritis.
Items | Standards | Results |
Appearance | White or off-white solid powder | White solid powder |
Identification | By IR | Complies |
By HPLC | Complies | |
Solubility | Slightly soluble in water, very slightly soluble in methanol, hardly insoluble in ethanol, acetone and acetonitrile | Complies |
Loss on Drying | ≤ 0.50% | 0.32% |
Heavy Metal | ≤ 10ppm | Complies |
Residue on Ignition | ≤ 0.20% | 0.05% |
Enantiomer | (SS) ≤0.1% | ND |
Citrate | 36.2% ~ 40.0% (on dried basis) | 37.3% |
Residual Solvents | Petroleum ether: ≤3000ppm | ND |
Ethanol: ≤5000ppm | 260ppm | |
Ethyl ether: ≤5000ppm | ND | |
Acetone: ≤5000ppm | ND | |
n-Butyl alcohol: ≤5000ppm | ND | |
Dichloromethane: ≤600ppm | ND | |
Related Substances | (RS+SR): ≤0.10% | ND |
Any single impurity: ≤0.10% | 0.07% | |
Total Impurities: ≤0.30% | 0.21% | |
Assay (HPLC basis on drying) | 99.0%~101.0% | 99.85% |
Particle Size | D90: ≤50µm | 27.61µm |
Reference Standard | In-house Standard | |
Conclusion | The product complied to In-house standard. | |
Storage | Preserve in tight,light-resistant containers in a cool place |