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CAS 540737 -29-9 Tofacitinib Citrate with Highest Quality

China CAS 540737-29-9 Tofacitinib Citrate with Highest Quality, Find details about China Tofacitinib Citrate, Tofacitinib Intermediate from CAS 540737-29-9 Tofacitinib Citrate with Highest Quality

Model NO.
Tofacitinib Citrate
Other Name
Tofacitinib Intermediate
Content
Pure Tofacitinib Citrate
Usage
Healthcare Supplement
MOQ
1kg
Appearance
White Powder
Stock
Sufficient
CAS Number
540737-29-9
Trademark
Tofacitinib Citrate
Transport Package
Drum
Specification
25kg/Drum
Origin
China
Model NO.
Tofacitinib Citrate
Other Name
Tofacitinib Intermediate
Content
Pure Tofacitinib Citrate
Usage
Healthcare Supplement
MOQ
1kg
Appearance
White Powder
Stock
Sufficient
CAS Number
540737-29-9
Trademark
Tofacitinib Citrate
Transport Package
Drum
Specification
25kg/Drum
Origin
China

CAS 540737-29-9 Tofacitinib Citrate with Highest Quality

Non-GMO 

Gluten Free 

Dairy Free

No artificial colors or flavors

Clean & Pure Powder. No Fillers

Lab Tested for Verification & Guaranteed Purity

From our plant to your door step

CAS 540737-29-9 Tofacitinib Citrate with Highest Quality

Product Name:
Tofacitinib Citrate
CAS:
540737-29-9
MF:
C16H20N6O.C6H8O7
MW:
289.35

Tofacitinib citrate is an oral drug used for treating rheumatoid arthritis. It belongs to a class of drugs called Janus kinase (JAK) inhibitors. JAKs are enzymes (proteins) that regulate chemical signaling pathways that control biologic processes such as blood formation and the immune response that causes the pain, tenderness and swelling of inflammation. JAKs are found in many cells, especially stem cells in bones and joints. Inhibition of JAKs by tofacitinib prevents inflammation and tissue destruction that is associated with the inflammation of rheumatoid arthritis.

CAS 540737-29-9 Tofacitinib Citrate with Highest Quality

Tofacitinib citrate is a potent inhibitor of JAK3 (Janus kinase 3) with some JAK1 inhibitory activity as well. JAK3 blocks downstream STAT signaling resulting in potent inhibition of inflammatory cytokines with resultant immunosuppressive and anti-inflammatory activity.
Tofacitinib (formerly tasocitinib, CP-690550) for the treatment of rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease, and other immunological diseases, as well as for the prevention of organ transplant rejection.It is an inhibitor of the enzyme Janus kinase 3 (JAK3), which means that it interferes with the JAK-STAT signaling pathway that transmits information outside the cell into the cell nucleus, influencing DNA transcription.
Recently it has been shown in a murine model of established arthritis, tofacitinib rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue. This efficacy in this disease model correlated with the inhibition of both JAK1 and 3 signaling pathways, suggesting that tofacitinib may exert therapeutic benefit via pathways that are not exclusive to inhibition of JAK3.



CAS 540737-29-9 Tofacitinib Citrate with Highest Quality

ItemsStandardsResults
AppearanceWhite or off-white solid powderWhite solid powder
IdentificationBy IRComplies
 By HPLCComplies
SolubilitySlightly soluble in water, very slightly soluble in methanol, hardly insoluble in ethanol, acetone and acetonitrileComplies
Loss on Drying≤ 0.50%0.32%
Heavy Metal≤ 10ppmComplies
Residue on Ignition≤ 0.20%0.05%
Enantiomer(SS) ≤0.1%ND
Citrate36.2% ~ 40.0% (on dried basis)37.3%
Residual Solvents Petroleum ether: ≤3000ppmND
 Ethanol: ≤5000ppm260ppm
 Ethyl ether: ≤5000ppmND
 Acetone: ≤5000ppmND
 n-Butyl alcohol: ≤5000ppmND
 Dichloromethane: ≤600ppmND
Related Substances(RS+SR): ≤0.10%ND
 Any single impurity: ≤0.10%0.07%
 Total Impurities: ≤0.30%0.21%
Assay
(HPLC basis on drying)		99.0%~101.0%99.85%
Particle SizeD90: ≤50µm27.61µm
Reference StandardIn-house Standard
ConclusionThe product complied to In-house standard.
StoragePreserve in tight,light-resistant containers in a cool place
CAS 540737-29-9 Tofacitinib Citrate with Highest QualityCAS 540737-29-9 Tofacitinib Citrate with Highest Quality

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