Product Name: Indirubin

Appearance: Dark Red Acicular Crystal

Purity: 97%

Test Method: UV

CAS No.: 479-41-4

Molecular Formula: C16H10N2O2

Molecular Weight: 262.2628

Solubility: Soluble in ethyl acetate, acetone, chloroform, ether, insoluble in water, slightly soluble in

                ethanol.

Density: 1.417g/cm3

Boiling Point: 496.6°C at 760 mmHg

Flash Point: 207°C

Vapour Pressure: 5.34E-10mmHg at 25°C

Shelf Life: 2 years

Storage: Keep away from sunlight, sealed in dry place.

MOQ: 1kg

Indirubin is an active ingredient of anti-leukemia isolated from dried leaves of Isatis indigotica Fort. For the treatment of chronic myeloid leukemia, the total effective rate was 87.3%. In terms of reducing white blood cells effect, Indirubin is similar to Maryland, but better than Maryland in reducing liver. Its' blood and bone marrow mitigation effect is worse than Maryland, and has no cross tolenrance with Maryland.

Indirubin also has a certain effect on acute myeloid leukemia. It can be used for abnormal myelopathy and eosinophilia. Indirubin has inhibiting effect on a variety of transplanted animal tumors, and can destroy leukemia cells. With the effect of Indirubin, cells of degeneration and necrosis show swelling and soluble necrosis. Through experimental studies it is found that Indirubin can enhance the animal's monocyte-macrophage system's phagocytosis. Indirubin has no direct effect on protein synthesis. Its' inhibition of DNA synthesis is due to inhibition of DNA polymerase, affecting the polymerization of DNA. Indirubin metabolizes in liver and gallbladder after intravenous injection or intragastric administration. After 96 hours 76.03% Indirubin was eliminated by faeces. After taking this product, the mice's blood concentration gradually increased, after 12 hours it reached the peak, slowed down after a month, maintaining a long time. Indirubin is highly distributed in liver, gallbladder and gastrointestinal. Bioavailability was 46.48%.

Indication

Indirubin has anti-cancer effect. It is clinically used for the treatment of chronic myeloid leukemia.

Usage and Dosage

Adult Dosage: 50 ~ 300mg/day, generally 200mg/day, 3 to 4 times/day by taking orally until symptoms relieved or 3 months for a course of treatment.

Dosage From

Indirubin Tablet: 25mg; 50mg; 100mg.

(EYECHEM) Xi'an QingShuo import and export trade Co., Ltd. Is a source and supplier of plants ingredients by making use of local rich herbs resources and mature technology of plant extraction. We devote ourself to specialty food and nutraceutical industries. Such as herbs extracts, nutraceutical industries, pharmaceutical ingredients, food additives, cosmetics ingredients, agriculture husbandry ingredients, flavoring, etc. 

We have factory of 10 years history of production, Named "Xi'an QingYue biological technology Co., Ltd. (QINGHERB)". We have passed certification of KOSHER, HALAL, ISO9001 ISO22000, HACCP. In to try for GAP/GMP. Now, quality department has a lot of advanced testing equipment, such as high performance liquid chromatography (HPLC), gas chromatography (GC), evaporative light-scattering light detector (ELSD), etc. 

Its main products are Cytisine, Aesculetin/Aesculin, Puerarin/Pueraria flavone, Epimedium P. E(Icariin/Flavone), Tabersonine, Fungus/Mushroom extract, Ginseng extract, Fruit extract, Sophora japonica P. E. Rutin, Quercetin, Genistein. Camptothecine. 

We hope to become your stable and reliable partner in the plant extract industry. We will do our best to offer you the latest information of China health products raw materials as your reference. 

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Mr. Alex Hao with 10 years of experience at plant extract Market of China