china Ginsenoside Rb2 11021-13-9

Alias : 20-((6-o-alpha-l-arabinopyranosyl-beta-d-glucopyranosyl)oxy)-12beta-hydroxydammar-24-en-3beta-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside;

 

Ginsenoside Rb2 Chemical Structure

 

Price & Stock

Ginsenoside Rb2 is a 20(S)-protopanaxadiol glycoside extracted from ginseng, shows potent antioxidant and anticancer biological activities.

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Biological Activity

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In Vitro: Treatment of 0.1 to 10μM Rb2 promoted the proliferation of MC3T3-E1 cells, improved alkaline phosphatase (ALP) expression, elevated calcium mineralization and mRNA expressions of Alp, Col1a1, osteocalcin (Ocn) and osteopontin (Opn) against oxidative damage induced by H2O2. Importantly, Rb2 reduced the expression levels of receptor activator of nuclear factor kappa-B ligand (RANKL) and IL-6 and inhibited the H2O2-induced production of ROS [1]. Ginsenoside-Rb2 showed the highest protective activity, although other dammarane-type and oleanolic acid-type ginsenosides also induced a significant protection against HVJ [2]. Rb2 (3~30 μM), perfused into an adrenal vein for 90 min, inhibited ACh (5.32 mM)-evoked CA secretory response in a dose- and time-dependent fashion. Rb2 (10 μM) also time-dependently inhibited the CA secretion evoked by DMPP (100 μM, a selective neuronal nicotinic receptor agonist) and high K(+) (56 mM, a direct membrane depolarizer) [3]. 
In Vivo: Multiple administrations of ginsenoside-Rb2 after the intravenous inoculation of B16-BL6 melanoma cells resulted in a significant inhibition of lung metastasis as compared with the untreated control [1].

Chemical Information

 

Ginsenoside Rb1

Alias : (3beta,12beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside

 

Ginsenoside Rb1 Chemical Structure

 

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Ginsenoside Rb1 is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.

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Biological Activity

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In Vitro: Rb1 inhibited melanogenesis in α-melanocyte-stimulating hormone (α-MSH) -stimulated B16 cells in a dose-dependent manner, which collectively indicated that Rb1 may have skin-whitening effects and may be formulated into skin-whitening products for skin care [1]. 
In Vivo: Application of 0.56mg of ginsenoside Rb1 resulted in significant decrement of scar elevation index, in comparison with control and lower dosage groups, furthermore achieved broader and randomly arranged collagen fibers resembling findings in normal dermis. Ginsenoside Rb1 concentration inversely correlated with the mRNA expression and immunohistochemical reactivity of scar related factors; MMP2, TIMP1, α- SMA, and TGF-β1 [2]. Ginsenoside Rb1 treatment...

Chemical Information

90985-77-6
Ginsenoside Ra3

Alias : (3beta,12beta)-12-hydroxy-20-((o-beta-d-xylopyranosyl-(1→3)-o-beta-d-glucopyranosyl-(1→6)-beta-d-glucopyranosyl)oxy)dammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside

 

Ginsenoside Ra3 Chemical Structure

 

Price & Stock

Ginsenoside Ra3 is extracted from roots and rhizomes of Panax ginseng, shows potent antioxidant biological activity.

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Biological Activity

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In Vitro: Plasma 20(S)-protopanaxadiol and 20(S)-protopanaxatriol could be used as pharmacokinetic markers to reflect the subject's microbial activities, as well as the timely-changes and interindividual differences in plasma levels of their respective oxidized metabolites. [2]. 
In Vivo: After ingestion of Sanchi extract, ginsenosides Ra3, Rb1, Rd, Rg1, F1, Rh1, and notoginsenoside R1 were measured in plasma samples. Deglycosylated metabolites Compound-K, protopanaxadiol, and protopanaxatriol were also detected in plasma. Notably, several metabolites of protopanaxadiol and protopanaxatriol were found in human plasma and characterized, the plasma concentrations of which were significantly higher than those of the circulating ginsenosides. Conclusion: Although the ginsenoside aglycones protopanaxadiol and protopanaxatriol were not contained in the test Sanqi extract, their oxidized metabolites represented a class of major circulating compounds after ingestion of the herbal extract to humans. [1]. The PK profiles of the Sanqi ginsenosides in humans were comparable to those found in rats. Slight interspecies differences could have been due to humans being relatively poor biliary excretors compared with rats.[3].

Chemical Information

Ginsenoside Ra2

Alias : (3beta,12beta)-12-hydroxy-20-((o-beta-d-xylopyranosyl-(1→2)-o-alpha-l-arabinofuranosyl-(1→6)-beta-d-glucopyranosyl)oxy)dammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside

 

Ginsenoside Ra2 Chemical Structure

 

Price & Stock

Ginsenoside Ra2 is extracted from roots and rhizomes of Panax ginseng.

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Biological Activity

IC50 Value & Target: 
In Vitro: Have no relevant experimental datas. 
In Vivo: Have no relevant experimental datas.

Chemical Information

Ginsenoside Ra1

Alias : (3beta,12beta)-12-hydroxy-20-((o-beta-d-xylopyranosyl-(1→4)-o-alpha-l-arabinopyranosyl-(1→6)-beta-d-glucopyranosyl)oxy)dammar-24-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside

 

Ginsenoside Ra1 Chemical Structure

 

Price & Stock

Ginsenoside Ra1 is extracted from roots and rhizomes of Panax ginseng, shows inhibitory effects on protein tyrosine kinase.

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Biological Activity

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In Vitro: Ra1 and Ro showed significant inhibitory effects on PTK activation induced by H/R. Dose-response experiments revealed that ginsenoside-Rb1 was the most active compound and it completely blocked PTK activation at a wide range of concentrations. Most protopanaxadiol-type ginsenosides and some protopanaxatriol type saponins also showed significant effects on PTK activation.[1]. 
In Vivo: Have no relevant experimental datas.

Chemical Information

Ginsenoside Ro

Alias : Chikusetsusaponin 5; Chikusetsusaponin V; Polysciasaponin P3; (3beta)-28-(beta-d-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 2-o-beta-d-glucopyranosyl-beta-d-glucopyranosiduronic acid

 

Ginsenoside Ro Chemical Structure

 Datasheet Download

• Ginsenoside-Ro .pdf

Price & Stock

Ginsenoside Ro, the predominant ginsenoside in the rhizome, is reported to have anti-inflammtory, anti-hepatitic activities, and showed inhibitory activity against 5αR with IC(50) value of 259.4 μm.

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Biological Activity

IC50 Value & Target: 259.4 μm (for 5α-reductase ) 
In Vitro: Ginsenoside Ro exhibited suppressive activities on reactive oxygen species and matrix metalloproteinase-2 elevation in UV-B-irradiated fibroblasts. Ginsenoside Ro could overcome the reduction of the total glutathione contents in UV-B-irradiated fibroblasts. In IL-1β-induced rat chondrocytes, ginsenoside Ro exerted anti-apoptosis and anti-inflammation. Ro could improve IL-1β-induced chondrocytes viability. Ginsenoside Ro could suppress IL-1β-induced apoptosis by inhibiting levels of Bax and Bad, decreasing p53 phosphorylation and promoting the expression of Bcl-xL and PCNA. Ginsenoside Ro inhibited caspase 3 activity. IL-1β-induced inflammation and matrix degration were also alleviated by Ginsenoside Ro with down-regulating the expression of MMP 3, MMP 9 and COX-2. Moreover, ginsenoside Ro inhibited NF-κB p65 phosphorylation induced by IL-1β [2]. 
In Vivo: Topical administration of ginsenoside Ro (0.2 mg/mouse) to shaved skin inhibited hair re-growth suppression after shaving in the testosterone-treated C57BL/6 mice. Ginsenoside Ro showed inhibitory activity against 5αR with IC(50) value of 259.4 μm [3].

Chemical Information

English Name: Ginseng P.E
Latin Name: Panax ginseng C.A. Mey.
Source of Plant: China is the origin of ginseng and has 2, 000 years of medical history in China; as the rare materia medica known all around the world, it has been included in many countries Pharmacopoeia. Ginseng Panax locates in the northeast region of China, North Korea and the Far East region of the former Soviet Union.
Used Part: Extracted and refined from the Dried Root of panax ginseng
 
Active Ingredient: Total Ginsenosides
 
1)Ginsenoside Rg1
Molecular Formula :C42H72O14
Molecular Weight :801.02
CAS Number:22427-39-0  
 
2)Ginsenoside Rb1
Molecular Formula :C54H92O23
Molecular Weight :1109.31
CAS Number:41753-43-9
 
3)Ginsenoside Re
Molecular Formula :C48H82O18
Molecular Weight :947.16
CAS Number:52286-59-6
 
Specification: Total Ginsenosides content 10%-80%
Characteristic:
Appearance:Yellow-White powder
Odor: Special Ginsenoside aroma, bitter taste
Solubility: 100% Soluble in Water
 
Function:
Enhance the immune system; can resist caducity and fatigue, nourishing brain; Regulate nerve system and improve human hematopoietic function, promote the function of metabolism; reduce blood sugar, treat coronary heart disease, angina pectoris, bradycardia, arrhythmia, ventricular, extrasystole. Irregular blood pressure, weak nerves resulting from child-birth; Enhance memory, skin cell activation, enhance the skin elasticity, reduce furrow.  
 
Application:
Medicine and health industry, cosmetology and cosmetics industry, and food additives. In many countries, ginseng is one of the most popular plants tonics.
 
Shelf Life: Two years when properly stored.
Storage: Store in Cool and dry place, keep sealed and keep away from strong light, hight temperature.
Packing: Double plastic bag of foodstuff inside, cardboard drum outside, (25kg/drum)
 


 
(EYECHEM) Xi'an QingShuo import and export trade Co., Ltd. Is a source and supplier of plants ingredients by making use of local rich herbs resources and mature technology of plant extraction. We devote ourself to specialty food and nutraceutical industries. Such as herbs extracts, nutraceutical industries, pharmaceutical ingredients, food additives, cosmetics ingredients, agriculture husbandry ingredients, flavoring, etc. 

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Its main products are Cytisine, Aesculetin/Aesculin, Puerarin/Pueraria flavone, Epimedium P. E(Icariin/Flavone), Tabersonine, Fungus/Mushroom extract, Ginseng extract, Fruit extract, Sophora japonica P. E. Rutin, Quercetin, Genistein. Camptothecine. 

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