English Name : Lidocaine

English Name: Xylocaine

CAS : 137-58-6

EINECS number : 205-302-8

Molecular formula : C14H23N2O

Molecular Weight: 235.3447

Appearance : White Crystalline Powder

Lidocaine Descriptions:

Lidocaine is a local anesthetic, also known as sicaine, has been replaced in recent years, procaine, widely used in cosmetic plastic surgery in local infiltration anesthesia, can inhibit the nerve cell membrane sodium channel blocking nerve excitability and Conduction. Lidocaine lipophilic and protein binding rate is higher than procaine, cell penetration ability, rapid onset, the role of a long time, the interaction intensity is 4 times that of procaine.

Lidocaine for infiltration anesthesia, epidural anesthesia, local anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia, reduce the side effects of lidocaine poisoning, can join anesthesia adrenalin e.

Applications:

1)Local numbing agent

The efficacy profile of lidocaine as a local anesthetic is characterized by a rapid onset of action and intermediate duration of efficacy. Therefore, lidocaine is suitable for infiltration, block, and surface anesthesia. Longer-acting substances such as bupivacaine are sometimes given preference for subdural and epidural anesthesias; lidocaine, though, has the advantage of a rapid onset of action.  vasoconstricts arteries, reducing bleeding and also delays the resorption of lidocaine, almost doubling the duration of anaesthesia. For surface anesthesia, several available formulations can be used for endoscopies, before intubations, etc. Buffering the pH of lidocaine makes local numbing less painful. Lidocaine drops can be used on the eyes for short ophthalmic procedures.





2)Heart arrhythmia

Lidocaine is also the most important class-1b antiarrhythmic drug; it is used intravenously for the treatment of ventricular arrhythmias (for acute myocardial infarction, cardioversion, or cardiac catheterization) if amiodarone is not available or contraindicated. Lidocaine should be given for this indication after defibrillation, CPR, and vasopressors have been initiated. A routine preventative dose is no longer recommended after a myocardial infarction as the overall benefit is not convincing.