Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1

China Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1, Find details about China Ibrutinib, CAS 936563-96-1 from Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1

Model NO.
dsl-Ibrutinib
CAS
936563-96-1
Storage Condition
Store at Rt
Lt
Wthin 72 Hours After The Payment
Trademark
DSL
Transport Package
1kg
Specification
25kg
Origin
China
HS Code
300120010
Model NO.
dsl-Ibrutinib
CAS
936563-96-1
Storage Condition
Store at Rt
Lt
Wthin 72 Hours After The Payment
Trademark
DSL
Transport Package
1kg
Specification
25kg
Origin
China
HS Code
300120010
Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder
CAS 936563-96-1
Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1
 

Ibrutinib is a bioavailable, small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon oral administration, ibrutinib binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is required for B cell receptor signaling, plays a key role in B-cell maturation, and is overexpressed in a number of B-cell malignancies. The expression of BTK in tumor cells is also associated with increased proliferation and survival.

 
 

 

 
Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1
 
Ibrutinib Application

PCI-32765 (Ibrutinib) is a high potent irreversible BTK inhibitor with an IC50 of 0.46 nM for the purified Btk.PCI-32765 (Ibrutinib) is highly active and well tolerated in CLL/SLL pts irrespective of high risk genomic abnormalities. Although follow-up is short, the high response rate and very low progression rate suggests that PCI-32765 (Ibrutinib) may be an important new targeted treatment approach for CLL pts. In ex vivo assays with whole bold, PCI-32765 (Ibrutinib) prevents the activation of human BCR with an IC50 of about 0.2 μM, while not influencing the activation of T cell. Treatment of CD40 or BCR activated CLL cells with PCI-32765 (Ibrutinib) results in inhibition of BTK tyrosine phosphorylation and also effectively abrogates downstream survival pathways activated by this kinase including ERK1/2, PI3K, and NF-κB. In addition, PCI-32765 (Ibrutinib) prevents activation-induced proliferation of CLL cells in vitro, and effectively inhibits survival signals provided externally to CLL cells from the microenvironment including soluble factors (CD40L, BAFF, IL-6, IL-4, and TNF-α), fibronectin engagement, and stromal cell contact. PCI-32765 is originally developed by Pharmacyclics. And participants is been invited for the phase I clinical trials.


Ibrutinib Function

Ibrutinib is a highly selective Bruton's tyrosine kinase (Btk) irreversible inhibitor.PCI-32765 (Ibrutinib) is a selective and irreversible pyrrolopyrimidine-based inhibitor of BTK with IC50 of 0.5 nM. [1] PCI-32765 binds irreversibly to Cys-481 in BTK and thus is only active with other kinases with such a modifiable cysteine residue. In DOHH2 cells, in which the BCR pathway can be activated by anti-IgG, PCI-32765 inhibits autophosphorylation of BTK (IC50, 11 nM), BTK's physiological substrate, PLCg (IC50, 29 nm), and downstream ERK (IC50, 13 nm). 




 

Test
Specification

Result

Appearance

White to Off-white solid

Off-white solid 

Identification by NMR

To match with the reference standard

Conforms

Purity

≥99.0%

99.5%

Total impurities

≤1.0%

0.5%

Single impurity

≤0.2%

0.2%

Chiral purity

≥99.0%

99.5%

KF

≤1.0%

0.5%

Solvent

MTBE≤3000ppm
THF≤72PPm
methyl alcohol≤3000ppm
EA:≤5000ppm
2-Me-THf≤720ppm

 

Conforms

Conclusion

Complies with in-house standard.
 


Feedback

Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1
 

Package
Iron drum & plastic drum packaging
200kg/drum
850kg/drum
200kg/drum&plastic drum
180kg/drum&plastic drum
25kg/plastic drum&Cardboard bucket

Plastic bag & kraft paper bag
1200kg/bag
50kg/plastic bag
25kg/plastic bag&kraft paper bag

Storage
Do not store in direct sunlight. Store in a tightly closed container.
Store in a cool, dry, well-ventilated area away from incompatible substances.
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation.
Avoid breathing dust, vapor, mist, or gas.
Avoid contact with skin and eyes. Keep container tightly closed. Avoid ingestion and inhalation.
Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1

Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1
 
Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1
Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1

Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1
 
Wuhan Disel Biotechnoloy Co., Ltd. (shorted as Disel Biotech) is located in Wuhan Donghu High-Tech Economic Development Zone, Wuhan is a big central city in China with convenient transportation abundant human resources. Disel Biotech is a modern advanced enterprise specializing in production and exportation of APIs, peptides, plant extracts etc., has invested and closed cooperated with domestic manufacturers qualified with GMP, DMF, FDA and Laboratories from famous Universities to meet the different customers′ needs from grams to tonnage quantity, which makes Disel Biotech to be more flexible and easily to supply highly cost-effective products with high quality and better service to customers. Disel Biotech is always stands in high starting, high stand and high quality, and masters strict management for production procedure and quality control. All the products must pass our quality test before being sending to customers.

Disel Biotech has business with more than 20 countries, of which our main markets include Central and South America, Southeast Asia, Central Asia, Africa, Middle East, Eastern Europe, Russia and more and more higher regulative markets are being developed as long as our deep ploughing and weeding. We will welcome market challenge forever.

Disel Biotech has been working closely with customers, delivering products and solutions that create value and competitive advantage while positively impacting the world we live in, as well as attentive service for the purpose to meet the demand of customers, spare no effort to create value for customers. We sincerely welcome new and old customers home and abroad to contact us for future business relationships and mutual success!


 
Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1
Anti-Cancer Pharmaceutical Grade API 99% Ibrutinib Powder CAS 936563-96-1

 

Why Choose us

1. Free samples
2. Re-ship services
3. Quality controlling
4. Factory price
5. Customized labels
6. Quality Assuarance
7. Drop shipping
8. 7 * 24 hours sales service
 
FAQ

1. Can I get some samples?
A:Yes, we can supply the free sample, but the shipping cost be paid by customer.
 
2. How can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3. Can you guarantee I can get my goods without any custom problem?
Yes, We have Reship Service.You can get your goods without any problem.

4. When you ship my order?
Normally within 3 to 5 days after confirming your payment.

5. How do you hide the products?
Our shipping agent is very professional.They can pack various professional discreet package for hidding the products

6. Is there any discount?
A: Yes, for larger quantity, we always support with better price.

7. Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
We'd like to accept Alipay, bank transfer, Western Union or Paypal or BTC

8. How long does it take to the goods arrived ?
It is Depending on your location,
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.