Black Pepper Extract Piperine is a flowering vine in the family Piperaceae, cultivated for its fruit, which is usually dried and used as a spice and seasoning. The fruit, known as a peppercorn when dried, is a small drupe five millimetres in diameter, dark red when fully mature, containing a single seed .Black pepper is native to South India and is extensively cultivated there and elsewhere in tropical regions.Piperine is responsible for the black pepper distinct biting quality. Piperine has many pharmacological effects and several health benefits, especially against chronic diseases, such as reduction of insulin-resistance,anti-inflammatory effects, and improvement of hepatic steatosis.