Hot Sell Cosmetic CAS 106685-40-9 Adapalene Powder

Product Name: Adapalene CAS No: 106685-40-9 MF: C28H28O3 MW: 412.52 Density:1.233 g/cm3 Melting Point: 319-322 °C Boiling Point: 606.3 °C at 760 mmHg Flash Point: 205.9 °C Appearance: white to off-white powder

Adapalene is a second-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions.  It is effective against acne conditions where comedones are predominant.

Analysis Item	Indexes
Characteristics	White or almost white crystalline powder
Identification	IR
Solubility	Practically insoluble in water and ethanol, sparingly soluble in tetrahydrofuran.
Appearance of solution	Solution must be clear and color NMT BY6 of EP
Heavy metals	≤20ppm
Loss on drying	≤0.5%
Sulfated ash	≤0.1%
Related substances	Impurity A:≤0.3% ImpurityD: ≤0.2% Impurity C:≤0.15% Unknown impurity:≤0.1% Total impurity: ≤0.5%
Residue solvents	Tetrahydrofuran:≤720ppm Acetic acid:≤5000ppm Methanol:≤3000ppm Dichloromethane:≤600ppm N,N-dimethyl formamide:≤880ppm
Assay(on dried basis)	98.0%-102.0%

Adapalene is a retinoid, in vivo and in vitro models of inflammation were demonstrated to have anti-inflammatory properties. Stable chemical structure of adapalene, in the air and light without decomposing. Mechanism and adapalene with formic acid and specific nuclear retinoic acid receptor combined with retinoic acid is the combination of adapalene and protein and binding of cytoplasmic receptors.
In mice to establish animal model of skin drug test proved that adapalene can treat acne, and acne vulgaris and differentiation process as a role. The mechanism of adapalene is considered by the hair follicle epithelium of normal cell differentiation and reduce microcomedo formation.