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Factory Antiemetic Drug Domperidone CAS 57808-66-9 with Best Price

China Factory Antiemetic Drug Domperidone CAS  57808-66-9 with Best Price, Find details about China Domperidone, CAS 57808-66-9 from Factory Antiemetic Drug Domperidone CAS  57808-66-9 with Best Price

Model NO.
Domperidone
CAS
57808-66-9
Mf
C22h24cln5o2
Water Solubility
Slightly Soluble in Water
Stability
Stable
Color
White
Chemical Properties
White Crystalline Powder
Uses
Anticholinergic Antispasmodics.
Properties
White or Almost White Powder
Therapeutic Function
Antiemetic
Deliver Time
7-10 Days
Shelf Life
2 Years
MOQ
10 Gram
Trademark
Biocar
Transport Package
Bag or Drum
Specification
1kg/Bag; 25kg/Drum
Origin
Guangzhou, Guangdong, China
HS Code
29333990
Model NO.
Domperidone
CAS
57808-66-9
Mf
C22h24cln5o2
Water Solubility
Slightly Soluble in Water
Stability
Stable
Color
White
Chemical Properties
White Crystalline Powder
Uses
Anticholinergic Antispasmodics.
Properties
White or Almost White Powder
Therapeutic Function
Antiemetic
Deliver Time
7-10 Days
Shelf Life
2 Years
MOQ
10 Gram
Trademark
Biocar
Transport Package
Bag or Drum
Specification
1kg/Bag; 25kg/Drum
Origin
Guangzhou, Guangdong, China
HS Code
29333990
Factory Antiemetic Drug Domperidone CAS    57808-66-9 with Best Price

Basic information
Product Name:Domperidone
Synonyms:kw-5338;midazol-1-yl)propyl)-4-piperidinyl)-;Domperidone,Motilium;5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one;5-Chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one;DoMperidone-d6;DoMperidone Sustained Release Pellets;DOMPERIDONE BASE
CAS:57808-66-9
MF:C22H24ClN5O2
MW:425.91
EINECS:260-968-7
Product Categories:VIOXX;Other APIs;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Dopamine receptor;Isotope Labelled Compounds
Mol File:57808-66-9.mol
Factory Antiemetic Drug Domperidone CAS  57808-66-9 with Best Price
Chemical Properties
Melting point 240-244°C
density 1.2904 (rough estimate)
refractive index 1.5400 (estimate)
storage temp. Store at RT
solubility DMSO: >10 mg/mL
form solid
pkapKa 7.90 (Uncertain)
color white
Water Solubility Slightly soluble in water.
Merck 14,3418
Stability:Stable. Incompatible with strong oxidizing agents.
InChIKeyFGXWKSZFVQUSTL-UHFFFAOYSA-N
CAS DataBase Reference57808-66-9(CAS DataBase Reference)
Factory Antiemetic Drug Domperidone CAS  57808-66-9 with Best Price
Usage And Synthesis
It is a kind of potent peripheral dopamine receptor antagonist with anti-vomiting and gastro-kinetic effects. It can affect the gastrointestinal motility to make the motility and tension of upper gastrointestinal tract return to normal and promote gastric emptying, enhancing the antral and duodenal motility, and coordinating the pyloric contraction. It can be used for the treatment of dyspepsia, and the nausea and vomiting induced by functional, organic, infection, dietary, radiation therapy or drug therapy. Because it almost has no inhibitory effect on dopamine receptor, there are no psychiatric and neurological side effects. And it can be used for treating the nausea caused by treating the Parkinson's disease through taking dopamine agonists. 
It can be used as anticholinergic antispasmodics. 
Domperidone is a kind of phenyl imidazole compounds with a strong role in promoting gastric motility and antiemetic effect. It can strengthen the tension of the sphincter of the lower part of the esophagus, preventing the stomach-esophageal reflux, enhancing the gastric motility, promoting the gastric emptying, coordinating the stomach and duodenal motility, suppressing nausea, vomiting, and effectively preventing the bile reflux without affecting the secretion of gastric juice. This product is a kind of peripheral dopamine receptor antagonists which can directly block the gastrointestinal dopamine receptors and exhibit the stimulating effect of gastric motility. It can enhance the esophageal peristalsis and the tension of esophageal sphincter. Because of its poor penetration through the blood brain barrier, it has almost no antagonism against the dopamine receptor of the brain, and therefore can excluding the side effects of the spirit and the central nervous system.
Domperidone is a commonly used antiemetic and gastro-kinetic drug with its appearance being white to light yellow powder and bitter taste. It is almost insoluble in water, slightly soluble in ethanol, easily soluble in lactic acid as well as soluble in citrate. This product is a kind of peripheral dopamine receptor antagonists with strong action. Domperidone can block the DA1 and DA2 receptor next to the synapses, antagonizing the inhibitory effect of dopamine on the postsynaptic cholinergic neurons of myenteric plexus and causing the stomach contractions. It can promote the motility and tension of digestive tract motility to return to normal function, promoting the emptying of stomach, increasing the motility of gastric antral and duodenum, coordinating the contraction of the pylorus as well as enhancing the esophageal peristalsis and the tension of the lower esophageal sphincter. Because it has a poor penetration capability through the blood-brain barrier with almost no antagonism on the dopamine receptor, you can rule out the side effects of spirit and the central nervous system side. It has rapid absorption after oral administration with the plasma concentration reaching peak after 15~30 min. In addition to the central nervous system, it is also widely distributed in other parts of the body. Owing to the presence of "first pass" hepatic metabolism and intestinal metabolism, it has a low oral bioavailability. The half-life of this product is 7h with 30% excreted through the urine at 24 h after the oral administration and about 60% excreted through faeces within 4 days. 
Indications
1, Digestion dysfunction symptoms caused by delayed gastric emptying, gastroesophageal reflux, chronic gastritis and esophagitis including nausea, vomiting, belching, abdominal fullness, abdominal pain, regurgitation caused burning sensation of mouth and stomach.
2, Parkinson's disease and nausea and vomiting caused by various kinds of reasons such as functional, infection, dietary, radiotherapy or drug therapy and dopamine receptor agonists (such as levodopa, bromocriptine) therapy.
3, it is suitable for treating migraine, dysmenorrhea, traumatic brain injury and intracranial lesions, radiation therapy and the nausea and vomiting caused by levodopa, nonsteroidal anti-inflammatory drug.
4, it is effective in treating the nausea and vomiting caused by various organic or functional gastrointestinal disorders in elderly people.
5, Domperidone is not effective in treating the vomiting caused by surgery or anesthesia and chemotherapy.
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Our Company
Guangzhou Biocar Pharmacy Co., Ltd., formerly known as Guangdong Yangye Pharmaceutical Factory established in 2005, is affiliated to Wuhan Biocar Group. With the rise of Internet +, company's business process is accelerating. The company's board of directors has decided to establish Guangzhou Yangye Biotechnology Co., Ltd. At the end of 2016. We have established close and stable cooperative relationship with over 420 manufacturers with long-term with consistent suppliers at India and China. Now the company has formed into a comprehensive chemical enterprise integrating scientific research, development, production, sales and service under all staffs' endless efforts.

Guangzhou Biocar Pharmacy Co., Ltd. is located near Zhujiang New Town, Tianhe District, one of the prosperous areas in Guangzhou. This helps facilitate business negotiations at home and abroad. It is a high-tech enterprise centered in Guangdong, radiating across our country and facing the world. And it is mainly engaged in the research, development and sales of new chemical raw materials, the custom synthesis and import and export of pharmaceutical intermediates and APIs, the agency sales of pharmaceutical chemicals, the research and development, production and sales of flavors, fragrances and chemical raw materials. Its factory covers an area of more than 4, 000 acres and has more than 600 employees. It has always adhered to the tenet of "Being faithful, cultivating harmony and achieving win-win cooperation" and treats every customer sincerely.

We are looking forward to cooperating with you sincerely, and making mutual benefit and brilliance!

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Factory Antiemetic Drug Domperidone CAS  57808-66-9 with Best Price
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Factory Antiemetic Drug Domperidone CAS  57808-66-9 with Best Price
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Factory Antiemetic Drug Domperidone CAS  57808-66-9 with Best Price

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