Tretinoin (Retin-A, Retinoic acid, Avita, Renova) is a derivative of Vitamin A and is used to treat comedonal acne, or whiteheads and blackheads. It works by affecting the growth of skin cells. It also prevents the formation of new comedones. Tretinoin is also the only topical medication that has been proven to improve wrinkles.

In topical form, this drug is pregnancy category C and should not be used by pregnant women.People using the topical form should not also use any cream or lotion that has a strong drying effect, contains alcohol, astringents, spices, lime, sulfur, resorc, or aspirin, as these may interact with tretinoin or exacerbate its side effects.

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