Chlorpheniramine maleate
Molecular Formula:C20H23ClN2O4
Formula Weight:390.86
CAS No.:113-92-8
Appearance:white crystalline powder
Purity:99.6%
Standard:BP standard

Chlorphenamine maleate is a medicine known as an antihistamine. When the body comes into contact with something it is allergic to, such as pollen, animal hair or fur, house dust or insect bites, it produces a chemical called histamine. This causes itchy, watery eyes, running or blocked nose, sneezing and rashes, which may itch. Chlorphenamine maleate blocks the effects of histamine and so reduces these symptoms.

Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing.

Chlorpheniramine inhibits the [3H]mepyramine binding to the histamine H1 receptor in guinea pig cortex with IC50 of 8.8 nM. Chlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 μM. Chlorpheniramine displaces of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells with IC50 of 66 nM. Chlorpheniramine displays antimalarial activity against CQS strain (D6) and MDR strain (Dd2) of P. falciparum with IC50 of 61.2 uM and 3.9 uM, respectively. Chlorpheniramine displays cytotoxicity against the proliferation of concanavalin A-induced murine splenic lymphocytes with IC50 of 33.4 μM. Chlorpheniramine treatment in human salivary gland cells more significantly inhibits the histamine-induced [Ca2+]i increase in a concentration-dependent manner with IC50 of 128 nM than that of carbachol-induced [Ca2+]i increase with an IC50 of 43.9 μM.

The COA of Chlorpheniramine maleate:

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Having been specialized in this field for years, we have rich experience and widespread sales network aro
und the word. Our steroide and hormones have been exported to overseas, like Europe, Africa, Asia, Ame
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ms customers encountered!

5. Experiential shopping
Besides raw steroid powder and liquid, we offer hormone solution and formula. We can teach you how to make.

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