Eif2b4 Polyclonal Antibody

China Eif2b4 Polyclonal Antibody, Find details about China Antibody, Protein from Eif2b4 Polyclonal Antibody

Model NO.
BS62501
Trademark
Bioworld
Specification
100ug/1mg
Origin
China
Model NO.
BS62501
Trademark
Bioworld
Specification
100ug/1mg
Origin
China
Catalog No.BS62501
Product NameEIF2B4 polyclonal antibody
ApplicationsWB
Alternative NameTranslation initiation factor eIF-2B subunit delta; eIF-2B GDP-GTP exchange factor subunit delta; EIF2B4; EIF2BD
Swiss-ProtQ9UI10
HostRabbit
ReactivityHuman,Mouse,Rat
Application_allWB: 1:500~1:1000 IHC: 1:50~1:200
ProductRabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&PurityThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&StabilityStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SpecificityEIF2B4 polyclonal antibody detects endogenous levels of EIF2B4 protein.
BiowMW~ 57 kDa
NoteFor research use only, not for use in diagnostic procedure.
ImmunogenSynthetic peptide, corresponding to Human EIF2B4.

  • Western blot (WB) analysis of EIF2B4 polyclonal antibody at 1:500 dilution LaneA:Hela whole cell lysate LaneB:MCF-7 whole cell lysate LaneC:PC12 whole cell lysate LaneD:CT26 whole cell lysate

Background

The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex eIF2B exists as a five subunit complex composed of eIF2Bα, eIF2Bβ, eIF2Bγ, eIF2Bδ and eIF2Bε. The eIF2B complex catalyzes the exchange of GDP for GTP on the eIF2 complex, following the interaction of eIF2/GTP with the 40S ribosomal subunit. Guanine nucleotide exchange factor (GEF) activity was exhibited by the eIF2Bε subunit alone, but it was greater in the presence of all five eIF2B subunits. Phosphorylation of eIF2 inhibits GEF activity of eIF2B, an inhibition that requires the eIF2Bα subunit.Eif2b4 Polyclonal Antibody
Eif2b4 Polyclonal AntibodyEif2b4 Polyclonal AntibodyEif2b4 Polyclonal AntibodyEif2b4 Polyclonal Antibody