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Product Name: | Paclitaxel |
Description: | Paclitaxel is a monomer diterpenoid compound extracted from Natural Plant Paclitaxel bark, is a kind of complex secondary metabolites, is currently understood only a drug can promote microtubule polymerization and stability of microtubules have been aggregated. |
CAS: |
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WF: | C47H51NO14 |
MW: | 853.91 |
EINECS: | 205-285-7 |
Product Categories: | antifungal agent |
TEST ITEM | SPECIFICATION |
Appearance | White or almost white crystalline powder |
Identification | FT-IR |
HPLC | |
NMR | |
Mass | |
Solubility | Soluble in ethanol, methanol, Chloroform, hardly soluble in water |
Specific Optical Rotation | -49.0º ~ -55.0º at 20°C |
Melting Point | 213°C-216°C |
Water | ≤1.0% |
Residual Solvent | Meets the requirements of ICH |
Ethyl Acetate | ≤5000ppm |
Acetone | ≤5000ppm |
Methanol | ≤3000ppm |
Acetic acid | ≤5000ppm |
Residual of volatile Solvents | Meets the requirements of ICH |
Chloroform | ≤60ppm |
Dichloromethane | ≤600ppm |
Hexane | ≤290ppm |
Conclusion | Conform with specification |
Storage | Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation. |
Shelf life | 2 years when properly stored |
1. Paclitaxel is a mitotic inhibitor drup used in the treatment of cancer.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
3. Paclitaxel has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
4. Paclitaxel is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.