China GMP Manufacture Prilocaine HCl 1786-81-8 Local Anesthesia Powder Free Sample, Find details about China Prilocaine HCl, Prilocaine from GMP Manufacture Prilocaine HCl 1786-81-8 Local Anesthesia Powder Free Sample
GMP manufacture Prilocaine HCl 1786-81-8 Local Anesthesia powder FREE sample
Name | Prilocaine HCL |
CAS number | 1786-81-8 |
Formula | C13H21ClN2O |
MW | 256.77 |
Purity | 99.98% Prilocaine |
Appearance | Prilocaine characteristic powder |
Application | Prilocaine is white and odorless crystal with bitter and numb taste. It is easily soluble in water, ethanol and organic solvents, but insoluble in ether. Aqueous solution in the case of acid and alkali do not break down, repeated autoclave rarely go bad. |
Stock | bulk in stock |
Shelf life | 2 Years |
Storage | PROCAINE should be stored in a well-closed container at low temperature, keep away from moisture, heat and light. |
Prilocaine Descriptions:
Prilocaine is a local anesthetic that is similar pharmacologically to lidocaine. Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns. Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. Currently, Prilocaine is used most often for infiltration anesthesia in dentistry.
Prilocaine is local anesthetic used to numb a person's skin and tissues. This medication is often made available as a cream that is topically applied, but it may also be available in an injectable form, which should always be administered by a specially trained professional. Its effects are not instant, but once a person experiences the associated numbness it may last for hours.
Prilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lö Fgren. In its injectable form (trade name Citanest), it is often used in dentistry.
Prilocaine topical is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.Prilocaine topical is used to numb the skin, or surfaces of the penis or vagina, in preparation for a medical procedure or to lessen the pain of inserting a medical instrument such as a tube or speculum.
Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline.
Prilocaine Applications:
Prilocaine topical is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.
Prilocaine topical is used to numb the skin, or surfaces of the penis or vagina, in preparation for a medical procedure or to lessen the pain of inserting a medical instrument such as a tube or speculum.
Prilocaine Usage And Synthesis:
Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline.
Anesthetic / Pain Killer | ||||
Tetracaine Base | 94-24-6 | Prilocaine hydrochloride | 1786-81-8 | |
Tetracaine hydrochloride | 136-47-0 | Proparacaine hydrochloride | 5875-06-9 | |
Lidocaine hydrochloride | 73-78-9 | Pramoxine hydrochloride | 637-58-1 | |
Linocaine Base | 137-58-6 | Procainamide hydrochloride | 614-39-1 | |
Benzocaine hydrochloride | 23239-88-5 | Ropivacaine hydrochloride | 98717-15-8 | |
Benzocaine Base | 94-09-7 | Articaine hydrochloride | 23964-57-0 | |
Procaine | 59-46-1 | Bupivacaine | 2180-92-9 | |
Procaine hydrochloride | 51-05-8 | Mepivacaine hydrochloride/Carbocaine | 1722-62-9 | |
Prilocaine | 721-50-6 | dibucaine hydrochloride | 61-12-1 |
Items | Standard | Results of analysis |
Appearance | White to class white powder | Class white powder |
Solubility | Almost insoluble in water, soluble in dimethyl sulfoxide, slightly soluble in solvent | Conforms |
Speicific rotation | +78.0°~+84.0° | +82.3° |
Ordinary impurities (Do not calculate isomer A+C) | Single impurity≤0.15% | 0.03% |
Total impurities≤1.0% | 0.09% | |
Calculate isomer | A≤0.15% | 0.02% |
B≤0.1% | Not detected | |
C≤0.1% | Not detected | |
Loss on drying | ≤0.5% | 0.31% |
Residue on ignition | ≤0.1% | Conforms |
Heavy metal | 20ppm | Conforms |
Assay | 97.5%-102.0% | 99.8% |
Conclusion :The test results conform with USP36. |
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