Good Quality Novel Pancreatic Lipase Inhibitor Cetilistat CAS 282526-98-1 Cetilstat
China Good Quality Novel Pancreatic Lipase Inhibitor Cetilistat CAS 282526-98-1 Cetilstat, Find details about China Cetilistat, CAS 282526-98-1 from Good Quality Novel Pancreatic Lipase Inhibitor Cetilistat CAS 282526-98-1 Cetilstat
Product Name: Cetilistat
Synonyms: cetilistat;Cetilistat(Alt-962);Cetilstat;2-(Hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one;2-(Hexadecycloxy)-6-methyl-4H-3,1-benzoxazin-4-one;New alistat;2-hexadecoxy-6-methyl-3,1-benzoxazin-4-one;Cetilistat (ATL-962)
CAS: 282526-98-1
MF: C25H39NO3
MW: 401.58
EINECS: 621-260-7
Melting point: 72.0 to 76.0 °C
Boiling point: 509.7±43.0 °C
Density: 1.02
Storage temp.: Store at RT
Appearance: Off-white Powder
Description:
Cetilistat (also known as ATL-962) was approved in September 2013 by the Japanese Ministry of Health, Labor and Welfare for the treatment of obesity, limited to patients with both type 2 diabetes mellitus (T2DM) and dyslipidemia, and with a body mass index (BMI)25 kg/m2 in spite of dietary treatment and/or exercise therapy. As with orlistat, cetilistat works via inhibition of pancreatic lipases in the gut to inhibit fat absorption and thereby reduce caloric uptake from diet. The medicinal chemistry program has not been described in the scientific literature, but the patent describing cetilistat also describes the synthesis of analogs with varied aryl substituents and lipophilic tails. The synthesis of cetilistat involves condensation of a hexadecylcarbonochloridate with 2-amino-5-methylbenzoic acid; other analogs were synthesized by varying the carbonochloridate and 2-aminobenzoic acid components. Cetilistat is a potent inhibitor of human and rat pancreatic lipase with IC50s of 15 and 136 nM, respectively, with little inhibition of trypsin or chymotrypsin.
Uses:
A novel pancreatic lipase inhibitor for the treatment of obesity in both diabetic and non-diabetic patients.
1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years.
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Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect.
Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other areas in the world. We have established close and stable cooperative relationships with over 200 domestic pharmaceutical and chemical enterprises. With high quality and favorable price, we′ re pleased to get your inquiry and we will reply you as soon as possible.
We will continue to forge ahead and strive hard for excellence, keep on exploring and progressing to develop more high-tech products with superior quality, to satisfy increasing demand of the clients, and create more value for our partners!
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Hubei Yuanmeng Biological Technology Co., Ltd.
Room 3820, Building 2, Vanke Golden City, Hongshan District, Wuhan, Hubei, China
Fiona Wei / Sales Manager
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