Quality  Guaranteed Tofacitinib Citrate CAS 540737-29-9 for Rheumatoid Arthritis 

 

 

Items	Standards	Results
Appearance	White or off-white solid powder	White solid powder
Identification	By IR	Complies
	By HPLC	Complies
Solubility	Slightly soluble in water, very slightly soluble in methanol, hardly insoluble in ethanol, acetone and acetonitrile	Complies
Loss on Drying	≤ 0.50%	0.32%
Heavy Metal	≤ 10ppm	Complies
Residue on Ignition	≤ 0.20%	0.05%
Enantiomer	(SS) ≤0.1%	ND
Citrate	36.2% ~ 40.0% (on dried basis)	37.3%
Residual Solvents	Petroleum ether: ≤3000ppm	ND
	Ethanol: ≤5000ppm	260ppm
	Ethyl ether: ≤5000ppm	ND
	Acetone: ≤5000ppm	ND
	n-Butyl alcohol: ≤5000ppm	ND
	Dichloromethane: ≤600ppm	ND
Related Substances	(RS+SR): ≤0.10%	ND
	Any single impurity: ≤0.10%	0.07%
	Total Impurities: ≤0.30%	0.21%
Assay (HPLC basis on drying)	99.0%~101.0%	99.85%
Particle Size	D90: ≤50µm	27.61µm
Reference Standard	In-house Standard
Conclusion	The product complied to In-house standard.
Storage	Preserve in tight,light-resistant containers in a cool place

Tofacitinib citrate is a potent inhibitor of JAK3 (Janus kinase 3) with some JAK1 inhibitory activity as well. JAK3 blocks downstream STAT signaling resulting in potent inhibition of inflammatory cytokines with resultant immunosuppressive and anti-inflammatory activity.

Tofacitinib (formerly tasocitinib, CP-690550) is a drug being investigated by Pfizer for the treatment of rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease, and other immunological diseases, as well as for the prevention of organ transplant rejection. It is an inhibitor of the enzyme Janus kinase 3 (JAK3), which means that it interferes with the JAK-STAT signaling pathway that transmits information outside the cell into the cell nucleus, influencing DNA transcription. Recently it has been shown in a murine model of established arthritis, tofacitinib rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue.

This efficacy in this disease model correlated with the inhibition of both JAK1 and 3 signaling pathways, suggesting that tofacitinib may exert therapeutic benefit via pathways that are not exclusive to inhibition of JAK3.

 

Hongkong XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

superiority of choosing our company

1, We guarantee deeply analyze and demonstrate, purity more than 99%
2, Factory outlet with priority price & large stock.
3, Special magic vacuum safe package & safe shipping way.All parcel shipments are shipped discreetly and secure under customers' all requests.
4, We promise reship policies if post failed or refund if you need.
5, Rate of passing customs is 99.9% including Russia,Australia and anyother.
6, TNT & UPS & DHL & EMS & Fedex or special line is available for you.Freight fee is all charge by seller.
7,Payment terms: Western Union, Moneygram ,bitcoin ,T/T for your choices.

Our services
1. Customer Satisfaction is our priority and guarantee for the future.
2. We co-develop products and projects with our partners.
3.Place of Origin China with Super quality by reasonable price.
4.When you meet problems in mineral processing, we can provide technical guidance.
5.We will ship the goods that you order from us by EMS, DHL, UPS, or FedEx.We will decided to choose which courier depend on Different countries.To find the best way to delivery the goods for you.
6.We will ship the goods within 5days after get your payments.If you want to cancel or change order, please tell me within 24hours after you finish the payment...So we both can make the best of the bad bargain.
Bulk Order: Shipped via sea or air, it's according to your requirement, delivery time is 7-15days after payment
7.if you have any other questions to consult me.please not hesitate to contact me any times.  

We pride ourself on our excellent team of well-known engineers, technological persons and young professional staffs to research and develop new process. We are also dedicated to provide custom synthesis and contract research services to industrial and academic entities on a short or long-term basis. In our lab and pilot-plant, compounds can be manufactured in the quantity from a few grams up to tens of kilos and beyond. we can supply the key intermediates for your project, which short your synthesis scheme and supply you a reference compound for bioassay or a high purity analytical standard.
 

Quality  Guaranteed Tofacitinib Citrate CAS 540737-29-9 for Rheumatoid Arthritis