China Geekee Analgesic Anti-Inflammatory Raw Powder CAS 71125-38-7 99% Purity Meloxicam, Find details about China Meloxicam, Chemical from Geekee Analgesic Anti-Inflammatory Raw Powder CAS 71125-38-7 99% Purity Meloxicam
Density | 1.6±0.1 g/cm3 |
---|---|
Boiling Point | 581.3±60.0 °C at 760 mmHg |
Melting Point | 255ºC |
Molecular Formula | C14H13N3O4S2 |
Molecular Weight | 351.401 |
Flash Point | 305.4±32.9 °C |
Exact Mass | 351.034760 |
PSA | 136.22000 |
LogP | 3.35 |
Vapour Pressure | 0.0±1.7 mmHg at 25°C |
Index of Refraction | 1.735 |
Water Solubility | DMSO: soluble |
Meloxicam, a non-steroidal anti-inflammatory agent, has been reported to inhibit the inducible isoform of Cox-2. Meloxicam is an inhibitor selective for Cox-2 (IC50 of 4.7 μM) over Cox-1 (IC50 of 36.6 μM). Studies suggest that Meloxicam is Cox-2 preferential,therefore it will probably not display a lower gastrointestinal toxicity than non-selective anti-inflammatory agents. This compound has been shown to also inhibit prostanoid synthesis in inflammatory cells. Additionally, Meloxicam has demonstrated the ability to non-competitively inhibit erythrocyte PGD (6-phosphogluconate dehydrogenase) activity in vitro.
Meloxicam is a non-steroidal antipyretic and analgesic anti-inflammatory drug, not a hormonal drug. It has strong anti-inflammatory, analgesic and antipyretic effects, and can selectively inhibit cyclooxygenase-2 (COX-2). Activity, thereby blocking prostaglandin synthesis, inhibiting prostaglandin biosynthesis at the Chemicalbook site of the inflammatory department is stronger than prostaglandin biosynthesis in the gastric mucosa or kidney, and is more safe than other NSAIDs. It is mainly used to relieve the symptoms of osteoarthritis, painful osteoarthritis, rheumatoid arthritis and joint spondylitis.For rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, soft tissue injury and pain. The overview, pharmacological effects, pharmacokinetics, synthesis, and use of meloxicam were edited by Shi Yan of Chemicalbook. (2015-11-23 Chemicalbook)
Adverse reactions
Indigestion, abdominal pain, nausea, diarrhea, elevated liver enzymes, dizziness, headache, rash, and anemia can occur. Occasionally edema, elevated blood pressure, mild serum creatinine or urea nitrogen abnormality, acute renal failure, gastric ulcer, gastric bleeding, gastric perforation, leukocytes, and thrombocytopenia.
PRODUCT NAME | ||
TEST ITEMS | SPECIFICATION | RESULTS |
Description | White Or Almost White Crystalline Powder | White Powder |
Identification | Infrared Absorption | Positive |
Assay | 97.0~103.0% | 99.2% |
Melting Point | 33~37ºC | 34.5~36.5ºC |
Loss On Drying | 0.5%max | 0.30% |
Organic Volatile Impurities | 2500PPm max | <1000PPm |
Residual Solvents | Meet the requirements.(USP29) | Confirms |
Chromatographic purity | sum of impurities:3.0%max | <3.0% |
Conclusion | The specification conform with USP32 standard |
Anti-inflammatory effects of meloxicam function by inhibiting the prostaglandin synthetase (cyclooxygenase 1 and 2) which results in a decrease of the synthesis of prostaglandins. As prostaglandins are chemicals that contribute to inflammation especially within joints, which leads to the common symptoms of pain, tenderness, and swelling associated with arthritis, inhibition of their synthesis can be associated with the analgesic and antipyretic effects of meloxicam. As a result, inflammation and its accompanying symptoms are reduced. Meloxicam starts to relieve pain about 30 to 60 minutes after administration.
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Xi′an Geekee Biotech Co., Ltd founded in 2010, is the production enterprisewhich professionally works On phytoextraction, chemical synthesis pharmaceutical material and medical intermediates. The company Covers an areaof 30.000 square meters, and has 150 employees. The company owns advancedcomplete Craft equipments and top quality inspection methods, Passed the GMPcertification, and has set up good Technical cooperation relationship with manystate scientific institutes.
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