Pharmaceutical Nootropic Powder CAS 104632-25-9 Pramipexole Dihydrochloride for Brain Improve
China Pharmaceutical Nootropic Powder CAS 104632-25-9 Pramipexole Dihydrochloride for Brain Improve, Find details about China Pramipexole Dihydrochloride, Pramipexole Dihydrochloride Monohydrate from Pharmaceutical Nootropic Powder CAS 104632-25-9 Pramipexole Dihydrochloride for Brain Improve
Basic Info.
Model NO.
JL-P
Product Name
Pramipexole Dihydrochloride
CAS
104632-25-9
Appearance
White Powder
Shipping Origin
China
Shelf Life
2 Years
Coa
Available
Storage
Cool Dried Storage
Package
1kg/Bag 25kg/Drum
Assay
Min 98%
MOQ
10 Gram
Sample
Available
Test Method
HPLC UV
Standard
Export Standard
Trademark
Julong
Transport Package
1kg/Foil Bag, 25 Kg/Drum
Specification
99%min
Origin
China
Model NO.
JL-P
Product Name
Pramipexole Dihydrochloride
CAS
104632-25-9
Appearance
White Powder
Shipping Origin
China
Shelf Life
2 Years
Coa
Available
Storage
Cool Dried Storage
Package
1kg/Bag 25kg/Drum
Assay
Min 98%
MOQ
10 Gram
Sample
Available
Test Method
HPLC UV
Standard
Export Standard
Trademark
Julong
Transport Package
1kg/Foil Bag, 25 Kg/Drum
Specification
99%min
Origin
China
Product Desciption
Products Description
Product Name: Pramipexole Dihydrochloride
Synonyms: Pramipexole Dihydrochloride;Pramipexole HCL;Pramipexole Hydrochloride;
Pramipexol HCL;(s)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride;
PramipexoleDihcl;(S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazol2HCltetrahydrobenzothiazol;(s)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine, Dihydrochloride
CAS:104632-25-9
MF: C10H19Cl2N3S
MW: 284.25
Melting point: 288-290°C
Chemical Properties: White Crystalline Powder
Usage: It is used for treating Parkinsonism. It can also be used as pharmaceutical raw materials.
Definition: ChEBI: A hydrochloride that is the anhydrous dihydrochloride salt of pramipexole.
Packing: As required
Pramipexole hydrochloride is a kind of drugs for treatment of Parkinson syndrome. It belongs to selective non-ergot dopamine receptor agonist. It was first successfully developed by Boehringer Ingelheim Company (Germany). It is a prescription drugs of dopamine receptor agonist applied in the largest amount of the world. In May, 1997, it had been approved for the first time by FDA for the treatment of idiopathic Parkinson's disease. It can reduce the symptoms and sign, and can either be used alone or in combination with levodopa. The trade name of the good marketed in the United States is Mirapex, which is the first drugs approved the FDA during the past six years for treatment of Parkinson syndrome. In 2007, it has entered into market in China with the commodity name being sifrol for the treatment of the signs and symptoms of idiopathic Parkinson's disease, being used either alone (without levodopa) or in combination with levodopa.
Function
Payment
Product Name: Pramipexole Dihydrochloride
Synonyms: Pramipexole Dihydrochloride;Pramipexole HCL;Pramipexole Hydrochloride;
Pramipexol HCL;(s)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride;
PramipexoleDihcl;(S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazol2HCltetrahydrobenzothiazol;(s)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine, Dihydrochloride
CAS:104632-25-9
MF: C10H19Cl2N3S
MW: 284.25
Melting point: 288-290°C
Chemical Properties: White Crystalline Powder
Usage: It is used for treating Parkinsonism. It can also be used as pharmaceutical raw materials.
Definition: ChEBI: A hydrochloride that is the anhydrous dihydrochloride salt of pramipexole.
Packing: As required
Pramipexole hydrochloride is a kind of drugs for treatment of Parkinson syndrome. It belongs to selective non-ergot dopamine receptor agonist. It was first successfully developed by Boehringer Ingelheim Company (Germany). It is a prescription drugs of dopamine receptor agonist applied in the largest amount of the world. In May, 1997, it had been approved for the first time by FDA for the treatment of idiopathic Parkinson's disease. It can reduce the symptoms and sign, and can either be used alone or in combination with levodopa. The trade name of the good marketed in the United States is Mirapex, which is the first drugs approved the FDA during the past six years for treatment of Parkinson syndrome. In 2007, it has entered into market in China with the commodity name being sifrol for the treatment of the signs and symptoms of idiopathic Parkinson's disease, being used either alone (without levodopa) or in combination with levodopa.
Function
1. It can relieve the motor symptoms of Parkinson's disease: Parkinson's disease is cause due to the dopamine deficiency resulting from the loss of dopaminergic neuron, leading to patients get a series of symptoms such as tremors, muscle rigidity, slow movement and so on. Pramipexole hydrochloride can highly selective act on dopaminergic D2 and D3 receptors, thereby, stimulating the release of dopamine in the brain and alleviating the motor symptoms. Shannon et al have shown that early Parkinson's disease patients who has received pramipexole monotherapy can effectively have their motor symptoms be within control and can maintain daily living. When being used in combination with levodopa, pramipexole can effectively improve both the ADL score and the motor symptoms score of patients with advanced Parkinson's disease, and thus making the life of the patients with advanced Parkinson's disease more active.
2. it can significantly alleviate the depressive symptoms associated with Parkinson's disease: the pramipexole hydrochloride is a kind of agonists of dopamine D2, D3 receptor. The dopamine D3 receptor system may be associated with the patient's mood and behavior. Since pramipexole can selectively stimulate the D3 receptor with a higher agonist efficacy than D2 receptors, it can significantly relieve symptoms of depression. In study of Barone (Italy) et al, when patients with Parkinson's disease had been treated with pramipexole or sertraline, the proportion of patients with alleviated depression symptoms in pramipexole group was significantly higher than that of the sertraline group. Researchers believe that dopamine agonists (pramipexole) can substitute antidepressants to treat the depression of patients with Parkinson disease.
Pramipexole has protective effect on damaged neurons as well as excellent control of the jitter symptom. It has the least side effects in the field of Parkinson syndrome. Moreover, it has a large scope for adjusting drug in later phase, which is good for the following treatment. It can prevent the nerve damage caused by long-term use of levodopa, delaying the time needed for levodopa treatment as well as reducing the dose of levodopa.
Specification
| Items | Specification | Results |
| Character | Off-white to white crystalline powder | Off-white crystalline powder |
| Solubility | Soluble in Water and Methanol, slightly soluble in Ethanol (96%), Almost insoluble | Complies |
| Identification | Specific Rotation -67-69.5° (on anhydrate basis) | -67.4 |
| (2) IR:Meets the requirement. | Complies | |
| (3) Optical purity Test | ||
| (4) Chloride Reaction | ||
| Clarity | Clear,not deeper than Y6. | |
| PH | 2.8-3.4 | 2.9 |
| Related Substances | Impurity A≤0.15% | 0.03% |
| Impurity B≤0.15% | Not detected | |
| Impurity C ≤0.15% | 0.04% | |
| Unknown single impurity ≤0.15% | 0.07% | |
| 0.1% Total Impurity≤0.5% | 0.18% | |
| Impurity D | Impurity D≤0. 5% | 0.05% |
| Water | 4.5%-6.5% | 5.7% |
| Heavy metals | ≤10ppm | complies |
| Sulfate Ash | ≤0.1% | 0.04% |
| Assay | 99.0%~101.0% | 99.4% |
Package & Delivery
By Express | By Air | By Sea | ||
Suitable for under 50kg Fast: 3-7 days High cost Door to door service, easy to pick up the goods | Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed | Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed | ||
Payment
Our services
1. All inquiries will be replied within 12 hours.
2. Dedication to quality, supply & service.
3. Strictly on selecting raw materials.
3. OEM/ODM Available.
4. Reasonable & competitive price, fast lead time.
5. Sample is available for your evaluation & Formulation development.
6. Faster delivery:Sample order in stock and 3-7 days for bulk production.
7. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.
8. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
About us
FAQ
About us
FAQ
Q1.What's your MOQ?
Our MOQ is 10pcs.
Q2: How to contact with us?
A: Click the Alibaba "Contact Supplier", send us message, you will get reply within 24 hours.
Q3:Which kind of payment terms do you accept?
A: For small order,you can pay on Alibaba by trade assurance. For bulk order, you can pay to our company's bank account.
Q4:Can you give me a discount price?
A: Sure,it depends on your quantity.
Q5:How can I get a sample?
A: You can discuss with us, we normally send sample by FEDEX, DHL,EMS. A few sample is free but you need to pay for the shipping cost.
Q6: How to confirm the Product Quality before placing orders?
A: You can get some sample, or we can send certificate of analysis or HPLC or NMR to you.
Q7:How can I make payment safe?
A: The whole transaction is under Alibaba's (Third party) inspection.
Q8: Is it possible to custom the labels with our own design?
A: Yes, just send us your artworks, you will get what you want.
Our MOQ is 10pcs.
Q2: How to contact with us?
A: Click the Alibaba "Contact Supplier", send us message, you will get reply within 24 hours.
Q3:Which kind of payment terms do you accept?
A: For small order,you can pay on Alibaba by trade assurance. For bulk order, you can pay to our company's bank account.
Q4:Can you give me a discount price?
A: Sure,it depends on your quantity.
Q5:How can I get a sample?
A: You can discuss with us, we normally send sample by FEDEX, DHL,EMS. A few sample is free but you need to pay for the shipping cost.
Q6: How to confirm the Product Quality before placing orders?
A: You can get some sample, or we can send certificate of analysis or HPLC or NMR to you.
Q7:How can I make payment safe?
A: The whole transaction is under Alibaba's (Third party) inspection.
Q8: Is it possible to custom the labels with our own design?
A: Yes, just send us your artworks, you will get what you want.
Q9.Can I get the sample?
Yes,we can send you the free sample after received the shipping cost(or you have forwarder,we can send to your forwarder).
Q10.Can you accept customized?
Yes,we can according your require to do it.
Q11.How do I place the order?
Don't worry, we are the gold supplier on Alibaba,and support Trade Assurance,after confirm the details, we will send you the payment link.
Yes,we can send you the free sample after received the shipping cost(or you have forwarder,we can send to your forwarder).
Q10.Can you accept customized?
Yes,we can according your require to do it.
Q11.How do I place the order?
Don't worry, we are the gold supplier on Alibaba,and support Trade Assurance,after confirm the details, we will send you the payment link.
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