Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Its main therapeutic use is in the palliative treatment of Alzheimer's disease. Common side effects include gastrointestinal upset. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier. Because it has a biological half-life of about 70 hours, it can be taken once a day.

Functions

Donepezil has been tested in other cognitive disorders including Lewy body dementia and vascular dementia, but it is not currently approved for these indications. Donepezil has been found to improve sleep apnea in Alzheimer's patients. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, CADASIL, and Down syndrome.

A 3 year NIH trial in patients with mild cognitive impairment reported that donepezil was superior to placebo in delaying rate of progression to dementia during the initial 18 months of the study but this was not sustained at 36 months. In a secondary analysis, a subgroup of individuals with the Apolipoprotein E4 genotype showed sustained benefits with donepezil throughout the study. However at this time donepezil is not indicated for prevention of dementia.

Recent studies suggest that Donepezil can improve speech in children with autism. The studies found that speech of autistic children who were mild to moderately affected appeared to improve from the use of Donepezil.

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1.Place of Origin China with Super quality by reasonable price.

2.Fast delivery by safe express way to all the country.

3.Has a number of highly qualified engineers and experts to provide guidance for reagents.

4.When you meet problems in mineral processing, we can provide technical guidance.

5.Sample order are welcome.

6.NMR,HPLC and COA can be supplied

7.We can supply sample for testing

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9.Payment method:WU,T/T,Moneygram and Bitcoin

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Welcome to send inquiry to us. Moderate price will be offered to you.

Hebei Atun Trading Co., Ltd  as a manufacturer and supplier of Pharmaceutical Intermediates in China. We mainly produce high purity pharmaceutical intermediates for research and lab use with high efficiency and good repute.We promise to cooperate with our partners by providing fast and high-quality service.Our products are well sold in Italy, Canada, Australia, UK, USA and so on.We hope to have a cooperate with friends from all over the world.