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Prevention and Long-Term Treatment of Asthma Montelukast Sodium CAS 151767 -02-1

China Prevention and Long-Term Treatment of Asthma Montelukast Sodium CAS 151767-02-1, Find details about China Montelukast Sodium, 151767-02-1 from Prevention and Long-Term Treatment of Asthma Montelukast Sodium CAS 151767-02-1

Model NO.
Montelukast Sodium
CAS
151767-02-1
Molecular Formula
C35h35clnnao3s
Molecular Weight
608.165
Trademark
CNSZGJ
Transport Package
Aluminum Bag; Drums
Origin
China
HS Code
4777103377
Model NO.
Montelukast Sodium
CAS
151767-02-1
Molecular Formula
C35h35clnnao3s
Molecular Weight
608.165
Trademark
CNSZGJ
Transport Package
Aluminum Bag; Drums
Origin
China
HS Code
4777103377
Product Description
Prodcut nameMontelukast Sodium
Standard packing materialAluminum foil bag inside, then waterproof bag or carton
AppearanceWhite Color
Purity99%
StoragePreserve in tight,light-resistant containers in a cool place

 

Prevention and Long-Term Treatment of Asthma Montelukast Sodium CAS 151767-02-1
Description:

Montelukast was launched as Singulair in Mexico and Finland for the management of mild to moderate asthma inadequately controlled by inhaled corticosteroids and short-acting beta2-agonists. Montelukast can be obtained by an seven-step synthesis from 3-[2(E)-(7-chloroquinolin-2-yl)vinyl] benzaldehyde. Montelukast is a potent, selective and orally active antagonist of the CysLT1 (formerly called LTD4) receptor, thus blocking the effects of the cysteinyl leukotrienes LTC4, LTD4 and LTE4 on microvascular permeability and the activation of eosinophils.

Montelukast represents the third molecule of this class which has been approved in asthma after pranlukast (1995) and zafirlukast (1996). Montelukast has been studied extensively in placebo-controlled clinical trials, in mildly or severe asthmatic patients challenged with LTD4 or exercise. A variety of acute bronchoconstricting challenges were inhibited or attenuated with all doses used.

Montelukast demonstrated clinically significant improvements in the parameters of asthma control associated with an appreciable improvement in quality of life., reducing days with asthma exacerbations and allowing significant tapering of corticosteroids. Montelukast is well-tolerated and only needs to be administered once a day.

Usage:

A selective leukotriene D4-receptor antagonist. Used as an antiasthmatic


 


Prevention and Long-Term Treatment of Asthma Montelukast Sodium CAS 151767-02-1


Prevention and Long-Term Treatment of Asthma Montelukast Sodium CAS 151767-02-1Prevention and Long-Term Treatment of Asthma Montelukast Sodium CAS 151767-02-1Prevention and Long-Term Treatment of Asthma Montelukast Sodium CAS 151767-02-1Prevention and Long-Term Treatment of Asthma Montelukast Sodium CAS 151767-02-1

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