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Introduction
Product name | Naproxen |
Appearance | WHITE Powder |
Assay | 99% |
CAS | 22204-53-1 |
MF | C14H14O3 |
MS | N/A |
Shelf Life | 24 months when properly stored |
Storage | Keep in a cool, dry, dark location |
Function
Arbidol is an antiviral treatment for influenza infection used in Russia and China. The drug is manufactured by Pharmstandard and since 2005 it has been the number one best-selling over-the-counter drug in Russia. Although some Russian studies have shown it to be effective, it is not approved for use in Western countries. Chemically, arbidol features an indole core, functionalized at all but one positions with different substituents. The drug inhibits viral entry into target cells and also stimulates the immune response.
Specification
Items | Specifications | Results | |
Appearance | White to almost white crystalline powder | white crystalline powder | |
Solubility | Soluble in acetone;slightly soluble in dehydrated alcohol,in methanol, and in acctonitrile,and in phosphate butter at PH values of 2 to5; practically insoluble in water | Conforms | |
Identification | IR:conforms to the spectrum of clarithromycin RS | Conforms | |
Specific optical rotation | -94.--102.(anhydrous substance,1 0mg/ml methylene chloride) | -98. | |
Sulphated ash | ≤ 0.2% | <0.01% | |
Appearance of solution | Clear or not more opalescent than reference suspension II and not more intensely coloured than reference solutionY7 | Conforms | |
Crystallinity | Meet the requirements | Conforms | |
pH | 8.0-10.0 | 8.7 | |
Water | ≤ 2.0% | 0.35% | |
Related substances | (1)any single impurity | ≤ 1.0% | 0.65% |
(2)any impurities greater than 0.4% | not more than 4 impurities | 1 | |
(3)total impurities | ≤ 3.5% | 2.0% | |
Heavy metals | ≤ 0.002% | 2.0% | |
Residul solvents | Ethanol ≤ 5000ppm | Not detected | |
Pyridine≤220ppm | Not detected | ||
Assay (on dried basis ) | 96.0% ~ 102.0%(anhydrous substance) | 97.3% | |
Conclusion | It complies with USP38 standard. |