China Buy Pharmaceutical Intermediate Raw Material Powder Misoprostol CAS 59122-46-2, Find details about China Misoprostol Powder, Misoprostol Supply from China Buy Pharmaceutical Intermediate Raw Material Powder Misoprostol CAS 59122-46-2
Quick detail :
Product name | Misoprostol | |
Appearance | white solid | |
Purity | 99%min | |
CAS No. | 59122-46-2 | |
EINECS No. | 664-288-5 | |
MF. | C22H38O5 | |
Grade Standard | Medicine Grade |
Misoprostol is used for the prevention of NSAID-induced gastric ulcers. It acts upon gastric parietal cells, inhibiting the secretion of gastric acid by G-protein coupled receptor-mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell. Because other classes of drugs, especially H2-receptor antagonists and proton pump inhibitors, are more effective for the treatment of acute peptic ulcers, misoprostol is only indicated for use by people who are both taking NSAIDs and are at high risk for NSAID-induced ulcers, including the elderly and people with ulcer complications. Misoprostol is sometimes coprescribed with NSAIDs to prevent their common adverse effect of gastric ulceration (e.g. with diclofenac in Arthrotec).
Misoprostol has other protective actions, but is only clinically effective at doses high enough to reduce gastric acid secretion. For instance, at lower doses, misoprostol may stimulate increased secretion of the protective mucus that lines the gastrointestinal tract and increase mucosal blood flow, thereby increasing mucosal integrity. However, these effects are not pronounced enough to warrant prescription of misoprostol at doses lower than those needed to achieve gastric acid suppression.
Specification
Ref. Standard | According to enterprise internal control standard inspection | |
Results Of Analysis Tests | ||
Test | Analysis Standard | Results |
Description | Light Yellowish Crystalline Powder | Light Yellowish Crystalline Powder |
Identification | (1)304nm,260nm. | confirmed |
Melting Point | 192°C~196°C | 192°C~196°C |
Specific Rotation | +124°~ +129° | +127.1° |
(HPLC) Related substances | (1)(Single):≤0.5% | 0.31% |
(2)(Total):≤1.0% | 0.59% | |
Loss On Drying | ≤0.5% | 0.1% |
Assay | ≥98.5% | 99.5% |
Sieve analysis | ≤30μm | confirmed |
Conclusion | This product conforms to enterprise internal control standards |