Supply Setipiprant 99% CAS 866460-33-5 for Anti-Hair Loss
China Supply Setipiprant 99% CAS 866460-33-5 for Anti-Hair Loss, Find details about China Setipiprant, CAS 866460-33-5 from Supply Setipiprant 99% CAS 866460-33-5 for Anti-Hair Loss
Basic Info.
Model NO.
VZ100
Stock
Available
CAS
866460-33-5
Transport Package
Drum/Bag
Specification
10g/50g/100g/500g/1KG
Origin
China
Model NO.
VZ100
Stock
Available
CAS
866460-33-5
Transport Package
Drum/Bag
Specification
10g/50g/100g/500g/1KG
Origin
China
Product Desciption
| Product Name | Setipiprant |
| CAS No. | 866460-33-5 |
| Molecular Formula | C24H19FN2O3 |
| Appearance | White powder |
| Assay | 99%min |
Setipiprant (INN) (developmental code names ACT-129,968, KYTH-105) is a drug originally developed by Actelion which acts as a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2). It was initially researched as a treatment for allergies and inflammatory disorders, particularly asthma, but despite being well tolerated in clinical trials and showing reasonable efficacy against allergen-induced airway responses in asthmatic patients, it failed to show sufficient advantages over existing drugs and was discontinued from further development in this application.
However, following the discovery in 2012 that the prostaglandin D2 receptor (DP/PGD2) is expressed at high levels in the scalp of men affected by male pattern baldness, the rights to setipiprant were acquired by Kythera with a view to potentially developing this drug as a novel treatment for baldness, with a previously unexploited mechanism of action. While it is too early to tell whether setipiprant will be an effective treatment for this condition, the favorable pharmacokinetics and relative lack of side effects seen in earlier clinical trials mean that fresh clinical trials for this new application can be conducted fairly quickly.
A phase 2A study is underway to evaluate the safety, tolerability, and efficacy of oral setipiprant relative to a placebo and the active comparator, finasteride, in 18 to 41 years old males with androgenetic alopecia.
However, following the discovery in 2012 that the prostaglandin D2 receptor (DP/PGD2) is expressed at high levels in the scalp of men affected by male pattern baldness, the rights to setipiprant were acquired by Kythera with a view to potentially developing this drug as a novel treatment for baldness, with a previously unexploited mechanism of action. While it is too early to tell whether setipiprant will be an effective treatment for this condition, the favorable pharmacokinetics and relative lack of side effects seen in earlier clinical trials mean that fresh clinical trials for this new application can be conducted fairly quickly.
A phase 2A study is underway to evaluate the safety, tolerability, and efficacy of oral setipiprant relative to a placebo and the active comparator, finasteride, in 18 to 41 years old males with androgenetic alopecia.
WuHan Vanz Pharm Inc
Wuhan Vanz Pharm Inc., which is specialized in custom synthesis and R&D in APIs and pharmaceutical intermediates, is located in Wuhan, China. We have established long-term cooperation with Shanghai Institute of Organic Chemistry, Wuhan University etc since 2011.
As a special team in organic chemistry and medical chemistry, we also support the technology of R&D on new product. We have strong advantages on the process research and product R&D, pay attention to researching and developing new technology which is self-owned intellectual property right. We are special at developing Drug for the respiratory, antidepressant, antivirus, etc. We have completed R&D of more than 20 APIs and intermediates after the company founded.
As a special team in organic chemistry and medical chemistry, we also support the technology of R&D on new product. We have strong advantages on the process research and product R&D, pay attention to researching and developing new technology which is self-owned intellectual property right. We are special at developing Drug for the respiratory, antidepressant, antivirus, etc. We have completed R&D of more than 20 APIs and intermediates after the company founded.
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