What is WAY 316606?

WAY 316606WAY 316606 is a sFRP-1 (Secreted frizzled-related proteins) inhibitor (Ki=80 nM); an endogenous antagonist of the secreted glycoprotein Wnt. IC50 value: 80 nM (Kd); 0.65 uM (EC50)Target: sFRP-1 Research showed that WAY 316606 bound to sFRP-1 with a K(D) of 0.08 microM and inhibited it with an EC(50) of 0.65 microM. WAY 316606 increased total bone area in a murine calvarial organ culture assay at concentrations as low as 0.0001 microM. Antiosteoporotic agents. 

WAY 316606 Benefits

WAY 316606 increased total bone area in a murine calvarial organ culture assay at concentrations as low as 0.0001 microM.

WAY 316606/ WAY316606 powder is a drug that was originally developed to help treat osteoporosis, a disease which weakens bones and makes them more fragile and likely to break.

How Does It Work?
The protein SFRP1 works as a modulator of the Wnt signaling pathways. These pathways - and more specifically the 'canonical'
pathway - lead to the regulation of gene transcription, which is crucial when determining what role genes will play.pathway has been identified as playing a part in the development of osteoporosis . This occurs as the pathway encourages the development of more bone-resorbing cells (osteoclasts) than bone-forming cells (osteoblasts). It works, then, by triggering the Wnt signaling pathway. This helps the two different cell types to be better differentiated,leading to less bone degradation and further bone growth.

But what does this have to do with hair loss?

While we'll discuss this more in-depth further down, Wnt signaling pathways also play a role in hair loss.
As hair follicles and their accompanying hairs develop, a process known as cell differentiation takes place. This occurs in the Dermal Papilla (DP), which is essentially the base of the follicle.
During this process, proteins are produced and delivered to various parts of the follicle. However, overexpression of certain proteins - particularly SFRP1 - can lead to quickened cycling and structural defects of the hair strand.
This all takes place as part of the Wnt signaling pathway, and is much more common in individuals with hair loss disorders.
As WAY regulates the Wnt signalling pathway, it's believed it can play a role in slowing down protein over-expression and result in regular hair growth and development.