Dexketoprofen belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the action of a substance in the body calledcyclo-oxygenase. Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, dexketoprofen prevents the production ofprostaglandins and therefore reduces inflammation and pain. Along with Peripheral analgesic action it possesses central analgesic action.
Characters | White crystalline powder |
Specific rotation | +56.0°~+60.0° |
Absorption coefficient | 425~451 |
Identification | (1) Positive reaction |
(2) Positive reaction | |
(3) ir | |
pH | 5.5~7.0 |
Related substances | Any individual impurity is NMT 0.5%, among which the number of impurities exceeding 0.2% is NMT 3. |
N-octyl-d-glucamine | NMT 0.2% |
L-ketoprofen | NMT 2.0% |
Loss on drying | NMT 0.5% |
Residue on ignition | NMT 0.1% |
Heavy metals | NMT 10ppm |
Residual solvents | (1) Ethanol: NMT 0.5% (5000ppm) (2) Ethyl acetate: NMT 0.5% (5000ppm) |
Assay (on dried basis) | 98.5%~101.0% of C20H25NO6 |
It have anti-inflammatory, analgesic, antipyretic effect.
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