Wucine Supply High Purity CAS 206361-99-1 99% Darunavir in Stock
China Wucine Supply High Purity CAS 206361-99-1 99% Darunavir in Stock, Find details about China Darunavir Powder, Darunavir Injection from Wucine Supply High Purity CAS 206361-99-1 99% Darunavir in Stock
Appearance:White Powder
CAS:206361-99-1
Melting point:74-76°C
Storage:Keep in cool dry place.
Darunavir is the latest weapon in the arsenal of agents to combat human immunodeficiency virus type 1(HIV-1).
As an HIV-1 protease inhibitor, its mechanism of action involves blocking the cleavage of the gag and gag-pol polyproteins into functional proteins essential for the production of infectious progeny virus;
the result is the production of immature, noninfectious viral particles.
Compared to predecessor HIV protease inhibitors, darunavir retains activity against resistant stains, a critical factor with the continual emergence of multidrug- resistant (MDR) mutants. Despite experiencing a 13-fold reduction in binding to MDR HIV-1 protease, this binding is 1.5 orders of magnitude tighter than the first-generation protease inhibitors.
| Physical&Chemical Control | ||
| ITEM | SPECIFICATION | RESULTS |
| Appearance | Fine powder | Complies |
| Colorl | White | Complies |
| Odor&Taste | Characteristic | Complies |
| Assay | ≥99% | 99.53% |
| Heavy Metals | ≤10ppm | Complies |
Pb | ≤2ppm | Complies |
As | ≤2ppm | Complies |
Hg | ≤1ppm | Complies |
Cad | ≤1ppm | Complies |
Sulphates | ≤300ppm | Complies |
| Ammonium | ≤200ppm | Complies |
| Iron | ≤10ppm | Complies |
Microbiological Control | ||
Total plate count | ≤1000CFU/G | Complies |
Yeast & mold | ≤100 CFU /G | Complies |
Total coli forms | ≤100 CFU /G | Complies |
E.coli | Negative | Negative |
| Salmonella | Negative | Negative |
Function & Application:
Darunavir exhibits less than a 10-fold decrease in susceptibility in cell culture against 90% of 3309 clinical isolatesresistant to amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, and tipranavir.In contrast, darunavir-resistant viruses display limited susceptibility to only tipranavir, suggesting limited cross-resistance between these two protease inhibitors.To avoid the issues of the peptide-based protease inhibitors, darunavir has evolved from a structure-based design effort to minimize peptidic features and reduce molecular weight and complexity.
Xi'an Wucine Bio Industries Inc is a national key high-tech enterprise,which mainly specializes in the R&D,operation and production of pharmaceuticals,and intermediates.Our company is situated in E&T development zone,xi'an city shaanxi,it is easy of access.Our company has independent R&D center,raw material synthesis workshop,has advanced quality instruments and equipmentm,several product patents there are 15 experts in our research team.We insist in innovation and produce high quality products.
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