The synthesis of the anti-AIDS drug Aprionavir requires two important intermediates, one of which is (S)-(+)-3- hydroxytetrahydrofuran. It can be synthesized by asymmetric hydroboration or hydrosilylation of dihydrofuran, asymmetric hydrogenation and reduction of 4- chloro-3- carbonyl butyrate-intramolecular etherification, enzymatic resolution of 3- hydroxytetrahydrofuran racemate, etc., but the optical purity of the product is not enough in most cases..