Supply Proline Supplement OEM L Proline

China Supply Proline Supplement OEM L Proline, Find details about China L-Proline, CAS 147-85-3 from Supply Proline Supplement OEM L Proline

Basic Info.

Trademark

Honray

Transport Package

Kraft Paper

Specification

25kg/drum

Origin

China

HS Code

2937290090

Trademark

Honray

Transport Package

Kraft Paper

Specification

25kg/drum

Origin

China

HS Code

2937290090

Product Desciption

Specifications
Food Grade:

Item	AJI92	EP8	USP36
Assay	99.0% ~ 101.0%	98.5% ~ 101.0%	98.5% ~ 101.5%
PH Value	5.9 ~ 6.9	---	---
Specific Rotation	-84.5° ~ -86.0°	-84.0° ~ -86.0°	-84.3° ~ -86.3°
Transmittance	≥98.0%	clear & colorless	---
Chloride(as Cl)	≤0.02%	≤0.02%	≤0.05%
Ammonium(as NH₄)	≤0.02%	≤0.02%	---
Sulfate(as SO₄)	≤0.02%	≤0.03%	≤0.03%
Iron(as Fe)	≤10ppm	≤10ppm	---
Heavy metal(as Pb)	≤10ppm	≤10ppm	≤15ppm
Other amino acids	conform	conform	conform
Loss on drying	≤0.30%	≤0.50%	≤0.40%
Residue on ignition	≤0.10%	≤0.10%	≤0.40%
Ninhydrin-positive substances	---	conform	---

Pharmaceutical Grade:

Item	AJI92	EP8	USP36
Assay	99.0% ~ 101.0%	98.5% ~ 101.0%	98.5% ~ 101.5%
PH Value	5.9 ~ 6.9	---	---
Specific Rotation	-84.5° ~ -86.0°	-84.0° ~ -86.0°	-84.3° ~ -86.3°
Transmittance	≥98.0%	clear & colorless	---
Chloride(as Cl)	≤0.02%	≤0.02%	≤0.05%
Ammonium(as NH₄)	≤0.02%	≤0.02%	---
Sulfate(as SO₄)	≤0.02%	≤0.03%	≤0.03%
Iron(as Fe)	≤10ppm	≤10ppm	---
Heavy metal(as Pb)	≤10ppm	≤10ppm	≤15ppm
Other amino acids	conform	conform	conform
Loss on drying	≤0.30%	≤0.50%	≤0.40%
Residue on ignition	≤0.10%	≤0.10%	≤0.40%
Ninhydrin-positive substances	---	conform	---

L-Proline is one of important amino acids which form protein in human boby. It is the essential material of amino acid transfusion. And it is also the main intermediate for compounding Captopril, Enalapril and other antihypertensive drugs. It has been widely used in food, medicine and other industries. It is made by fermentation of corn. So it is more safer.

1. Used as nutritional supplement.
2. Used as the materials of compound amino acid infusion. Used in malnutrition, protein deficiency disease, stomach disease, scald and protein supplement after surgery.

There are two kinds of L - proline. One is direct fermentation, using glucose and yellow short bacillus mutant or glutamic acid bacillus wild strains, L - proline obtained with microbial fermentation; 2 it is chemical synthesis to glutamic acid as raw materials, and anhydrous ethanol under the sulfuric acid catalytic esterification, and add triethanolamine to amine sulfate free, glutamic acid - delta - ethyl ester. Reoccupy metal reductant glutamic acid reduction - delta - ethyl ester, raw proline, finally the purification can be rough on the proline. Small craft take L - glutamic acid esterification said 147 g, into three bottle neck, add 1 L, anhydrous ethanol mix cool to 0 ºC, and then add 80 ml - H2SO4, at 0-5 ºC stirring reaction 1 h, 1 h at room temperature to continue response, response all clear. Under 20 ºC and to pH 8-8.5, precipitation white crystalline, 1 h at room temperature and stirring, let stand for 5 ºC cooling filtration, crystallization, washing with 95% ethanol, drained after vacuum drying, to glutamic acid ethyl - delta - about 141 g. Melting point of 178-180 ºC, the yield of 80% 83%. [alpha] 32 + 29.8 d (C = 1 g/ml 10% HCl). Reduction in three flask into glutamic acid ethyl - delta - 175 g, add distilled water, 875 ml, stir cool to 5 ºC, add in another KBH4 53.9 g, about 1 h adds, at room temperature and 1 h reaction, heat preservation 50 ºC reaction 3 h. Cooled to 0 ºC, add 6 mol/L HCl to pH4, filtering the filtrate, quick rough L - proline aqueous solution. Ion exchange resin - alumina column chromatography separation and purification raw will L - proline aqueous solution, with 4 ml/min flow entering into the 732 - H + resin exchange column charge 10 ml acid resin (1 g). First rinse with distilled water to neutral, then use 1 mol/L elution, collection of L - containing proline eluent (thin layer chromatography with silica gel G control). Condensed the eluent decompression to dry, then use a small amount of water dissolves, it into neutral alumina column, again with 60% ethanol elution solution (or a thin layer chromatography with silica gel G control).
Supply Proline Supplement OEM L Proline

What We Do

Hebei Honray Imp. & Exp. Co., Ltd. located in Shijiazhuang city, Hebei, China is wholly owned subsidiary by Honray Group. It was established in 2012, engaged in manufacturing and exporting Amino Acids, Sweetners, Food ingredients and Vitamins . The key products are including Glycine, L-lysine HCL, L-lysine sulphate, L-Phenylalanine, L-valine, L-Leucine, L-Isoleucine, L-Threonine, L-Proline, L-Methionine, DL-Methionine, Erythritol, Allulose, Xanthan Gum and some of Vitamins. Our product line covers the food industry, feed industry, health care industry and cosmetics industry. They are mainly exported to America, Europe and Southeast Asia etc.