99% High Purity Nmn Beta-Nicotinamide Monomucleotide Nmn Powder Nmn Nicotinamide Mononucleotide CAS. 1094-61-7 Beta-Nicotinamide Mononucleotide | |
CAS: | 1094-61-7 |
MF: | C11H15N2O8P |
MW: | 334.22 |
EINECS: | 214-136-5 |
Melting point: | 166 °C(dec.) |
storage temp: | 2-8°C |
Assay: | 99% |
Chemical Properties: | White to Yellowish lyophilized powder |
Definition A condensation product of nicotinamide and ribose 5-phosphate, in which the nitrogen of nicotinamide is linked to the (β) c-l of the ribose.
Uses
A product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice . It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
Uses β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.
Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.
β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.At 50-100 µM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 dia
Clinical Use
Nicotinamide adenine dinucleotide (NAD+)?exists in all living organisms and is well known as a coenzyme in oxidation?reduction reaction. Recent research has drawn attention to its relation to "sirtuin" represented by NAD+?dependent protein deacetylases, which is to regulate various life phenomena as aging, people are especially paying high attention to "Anti-aging effect". The turnover of the oxidized form of nicotinamide adenine dinucleotide (NAD+) has attracted interest in regard to longevity.?Meanwhile, sirtuin is NAD+?dependent and increase of cellular NAD+?level is expected to have similar effects to the STACs, thus nicotinamide mononucleotide, an intermediate of NAD+?biosynthesis, is also in the spotlight.
Product IntroductionNoopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester , a synthetic Nootropic molecule.
Noopept has a similar effect to Piracetam, in that it provides a mild cognitive boost after supplementation. Noopept also provides a subtle psychostimulatory effect.
Noopept has a much lower standard dose than piracetam (10-30mg, compared to 4800mg), and it provides a general neuroprotective effect after supplementation. This neuroprotective effect occurs during various states of cognitive trauma, including oxidative stress and physical trauma. There is, however, no evidence to suggest Noopept provides benefits for people with no cognitive ailments.
More studies are needed to determine the main mechanisms responsible for Noopept's neuroprotective effect.
Noopept is not a racetam (due to not having a 2-oxo-pyrrolidine skeleton),but is generally grouped together in the same category because it shares similar mechanisms of action with the racetam family, mainly modulation of the acetylcholine system, as well as modulation of AMPA receptors. It has close ties to the popular racetam family of nootropics that are known for their benefits on cognitive ability as well their neuroprotective properties. What makes Noopept a valuable nootropic in your toolbox is that its effects are felt almost immediately after ingestion.When compared to traditional racetams, it has been found to be, according to studies, 1000 times more potent than the prototypical racetam drug, piracetam.Noopept is a prodrug for the endogenous peptide cycloprolylglycine.As a result, Noopept can be taken in comparably smaller doses to produce the same results as that of Piracetam.
Memory and LearningNoopept is a nootropic supplement that's been getting a lot of attention lately.Noopept's most emphasized benefit is how it can enhance memory and improve the learning process. Noopept, like Piracetam, assists with memory formation, but with additional benefits not present in the latter, which are memory consolidation and memory retrieval. Noopept facilitates the proper management of all forms of stimuli as they are processed by the brain, which allows for better retrieval of memory. In other words, signals being processed by our senses are more streamlined as they are transported into our brains in the form of memory.
Through the continued use of Noopept, you will notice that you are able to process more information and be able to process them for use in your daily activities. You might even recall names, places, maybe a word spoken in a chance encounter, a song title that you thought you have forgotten before, and so on. Memory lapses will be a thing of the past, or at least kept to a minimum.
Noopept DosageDue to its incredible potency, the recommended dosage of Noopept is small, usually 10 to 20 mg taken as often as three times daily. Dosage should not exceed 40 mg in a 24-hour period. Since the body metabolizes Noopept rapidly, and it has a very short half-life in the human body, it is preferable to take multiple small doses versus one large dose, in order to properly benefit from Noopept.
Noopept StackingNoopept can be taken alone but also does very well in nootropic stacks with Piracetam and Choline for synergistic benefits.Because Noopept delivers results similar to piracetam, stacking the two may result in synergistic benefits. The two supplements work on two different neurotransmitters, glutamate and acetylcholine, respectively. Gaining enhanced functionality of both transmitters could create a tremendous boost to a variety of cognitive processes. Furthermore, adding a choline supplement to the stack could make the piracetam more effective and help to hold off headaches reported by some initial-stage Noopept users.
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