China API Supplier Sunitinib Malate / Sunitinib API / CAS #341031-54-7, Find details about China Sunitinib Malate, Sunitinib Malate Factory Supply from China API Supplier Sunitinib Malate / Sunitinib API / CAS #341031-54-7
Product Name | Sunitinib Malate |
Appearance | Pale yellow to off-white powder |
Assay | 99%min, 98.0% --101.0% |
Test | HPLC |
Certificate | ISO 9001 |
CAS | 341031-54-7 |
MF | C22H27FN4O2.C4H6O5 |
Storage Temperature | Cool Dry Place |
What is Sunitinib Malate ?Sunitiba Malate is an antineoplastic agent and a potent RTK inhibitor which includes Flk-1 (VEGFR2) as a primary target. It also is a potent, ATP-competitive inhibitor of VEGFR, PDGFR-β and c-Kit (KIT). Sunitiba Malate inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models. Sunitinib Malate is an inhibitor of c-Fms-CSF-1R, Flt-1, Flt-3/Flk-2, Flt-4, PDGFR-α and Ret. |
Sunitinib Malate has very good oral bioavailability, is highly efficacious
in a number of preclinical tumor models, and is well tolerated at efficacious doses.
Sunitinib malate is an inhibitor used in the treatment of advanced renal cell carcinoma
and gastrointestinal stromal tumors.
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