China ISO Factory Supply Hair Loss Treatment Setipiprant Powder CAS 866460-33-5 99% Setipiprant Powder Setipiprant, Find details about China 99% Setipiprant 866460-33-5, Setipiprant CAS 866460-33-5 from ISO Factory Supply Hair Loss Treatment Setipiprant Powder CAS 866460-33-5 99% Setipiprant Powder Setipiprant
Product Name:Setipiprant
Brand Name: ACT129968
CAS No.:866460-33-5
Molecular formula:C24H19FN2O3
Molecular weight: 402.42g/mol
Specification:Pharmaceutical Grade 99%
Appearance: Off-White Powder
Properties: Anti-Hair Loss,Baldness
Shelf Life :2 years
Storage:Room temperature, keep dry and away from light.
Description:
Setipiprant Powder (INN) (developmental code names ACT-129,968, KYTH-105) is a drug originally developed by Actelion which acts as a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2). It was initially researched as a treatment for allergies and inflammatory disorders, particularly asthma, but despite being well tolerated in clinical trials and showing reasonable efficacy against allergen-induced airway responses in asthmatic patients, it failed to show sufficient advantages over existing drugs and was discontinued from further development in this application.
However, following the discovery in 2012 that the prostaglandin D2 receptor (DP/PGD2) is expressed at high levels in the scalp of men affected by male pattern baldness, the rights to setipiprant were acquired by Kythera with a view to potentially developing this drug as a novel treatment for baldness, with a previously unexploited mechanism of action. While it is too early to tell whether setipiprant will be an effective treatment for this condition, the favorable pharmacokinetics and relative lack of side effects seen in earlier clinical trials mean that fresh clinical trials for this new application can be conducted fairly quickly.
A phase 2A study is underway to evaluate the safety, tolerability, and efficacy of oral setipiprant relative to a placebo and the active comparator, finasteride, in 18 to 41 years old males with androgenetic alopecia.
Test | Specification | Result |
Appearance | White to light yellow powder | Off white powder |
Identification | Positive | Conforms |
HPLC Purity | 98%+ | 99.68% |
Decision | Conformance to specification |
Function
Setipiprant is the drug for the treatment of hair loss dwindled, perhaps due more to commercial potential and chemical stability reasons than efficacy as the later studies of Setipiprant have focused on different chemical forms of the drug and combining it with various nanoparticles to enhance delivery.
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Xi'an Wucine Bio Industries Inc is a national key high-tech enterprise,which mainly specializes in the R&D,operation and production of pharmaceuticals,and intermediates.Our company is situated in E&T development zone,xi'an city shaanxi,it is easy of access.Our company has independent R&D center,raw material synthesis workshop,has advanced quality instruments and equipmentm,several product patents there are 15 experts in our research team.We insist in innovation and produce high quality products.
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