China Factory Direct Supply CAS 103-90-2 4-Acetamidophenol Best Price Paracetamol Raw Powder, Find details about China 103-90-2, Apap from China Factory Direct Supply CAS 103-90-2 4-Acetamidophenol Best Price Paracetamol Raw Powder
4-Acetamidopheno
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The chemiacal name of 4-acetaminophen is N-(4-hydroxy phenyl) acetamide and the trade name is paracetamol belonging to acetanilid antipyretic analgesics. It was first synthesized by Morse in 1878 and first used in clinic by VonMering in 1893. It has become an over the counter drug in the USA since 1955 and our country started production at the end of the 1950's. 4-acetaminophen is a white crystalline or a crystalline powder in appearance with melting point from 168ºC to 172ºC, odorless, slightly bitter taste, freely soluble in hot water or ethanol, dissolved in aceton, practically insoluble in cold water and petroleum ethe. It is stable below 45ºC but will be hydrolyzed into p-aminopheno when exposed to humid air, then oxidized further. The color grades gradually from pink to brown then to black, so it should be sealed and stored in a cool and dry place.
4-Acetamidopheno has the antipyretic activity by inhibiting the synthesis of hypothalamic thermoregulation prostaglandins and its strength of antipyretic effect is similar to aspirin. On the other hand, 4-Acetamidophenol can produce analgesic effect by inhibiting the synthesis of prostaglandins in the central nervous system and blocking impulses of nociceptive nerve endings, but weaker than aspirin. Compared with aspirin, 4-Acetamidophenol has minor irritation, few allergic reactions and other advantages. Its antipyretic and analgesic effect is similar, and the use of 4-acetaminophen increases due to limiting or banning using in many countries.
In clinical, it is mainly used for fever and headache caused by cold and relieving mild to moderate pain such as joint pain, muscle pain, neuralgia, migraine, dysmenorrhea, cancer pain, postoperative analgesia and so on. It can be used for patients who are allergic to aspirin, intolerant of aspirin, or unsuited for aspirin, such as patients with varicella, hemophilia and other hemorrhagic disease (patients having anticoagulant therapy included), as well as patients with slight peptic ulcer and gastritis. In addition, it also can be used for the synthesis of benorylate and used as asymmetric synthetic intermediates, photographic chemicals and stabilizer of hydrogen peroxid.
Density | 3.1 g/mL at 25 °C(lit.) |
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Boiling Point | 1291 °C |
Melting Point | 250°C |
Molecular Formula | AlF3 |
Molecular Weight | 83.977 |
Flash Point | 1250°C |
Exact Mass | 83.976746 |
Water Solubility | SLIGHTLY SOLUBLE |
1. Stored in a clean, cool and dry area; keep away from strong, direct light.
2. Shelf Life is 2 years when properly stored.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (36*36*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
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2. For rush delivery, please contact our sales team for particular arrangement
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4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
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