CAS 88495 -63-0 Artesunate

China CAS 88495-63-0 Artesunate, Find details about China Artesunate, 88495-63-0 from CAS 88495-63-0 Artesunate

Basic Info.

Model NO.

CAS 88495-63-0 Artesunate

384.42

Melting Point

132-135 C

Density

1.3+-0.1 g/cm3

Boiling Point

507.1+- 50.0 .C at 760 Mmhg

Flashing Point

175.6+-23.6 °c

Storage

Cool Dry Place

Shelf Life

24 Months

Trademark

HNB

Transport Package

1kg/Bag. 25kg/Drum

Specification

Artesunate

Origin

China

Model NO.

CAS 88495-63-0 Artesunate

384.42

Melting Point

132-135 C

Density

1.3+-0.1 g/cm3

Boiling Point

507.1+- 50.0 .C at 760 Mmhg

Flashing Point

175.6+-23.6 °c

Storage

Cool Dry Place

Shelf Life

24 Months

Trademark

HNB

Transport Package

1kg/Bag. 25kg/Drum

Specification

Artesunate

Origin

China

Product Desciption

Product Name	Artesunate
CAS NO	88495-63-0
Appearance	White crystal powder
Plants source	Composites Artemisia annua L. leaf.

Artesunate is used primarily as treatment for malaria; it has also been shown to be >90% efficacious at reducing egg production in Schistosoma haematobium infection. According to WHO intravenous AS is the drug of choice for severe malaria both in children and adults where there is low transmission.In regions where transmission is high, randomized trials among Asian adults and African children strongly advocates the use of artesunate over quinine as the treatment of choice for falciparum malaria. Artesunate is prepared from dihydroartemisinin (DHA) by reacting it with succinic acid anhydride in basic medium. Pyridine as base/solvent, sodium bicarbonate in chloroform and catalyst DMAP (N,N-dimethylaminopyridine) and triethylamine in 1,2-dichloroethane have been used, with yields of up to 100%. A large scale process involves treatment of DHA in dichloromethane with a mixture of pyridine, a catalytic amount of DMAP and succinic anhydride. The dichloromethane mixture is stirred for 6-9 h to get artesunate in quantitative yield. The product is further re-crystallized from dichloromethane. alpha-Artesunate is exclusively formed (m.p 135-137C).